Ogura Sayoko, Shimosawa Tatsuo
Division of Laboratory Medicine, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan.
Curr Hypertens Rep. 2014 Aug;16(8):452. doi: 10.1007/s11906-014-0452-x.
Oxidative stress plays a pivotal role in various pathological conditions, including hypertension, pulmonary hypertension, diabetes, and chronic kidney disease, with high levels of oxidative stress in target organs such as the heart, pancreas, kidney, and lung. Oxidative stress is known to activate multiple intracellular signaling, which induces apoptosis or cell overgrowth, leading to organ dysfunction. As such, targeting oxidative stress is thought to be effective in protecting against organ damage, and measuring oxidative stress status may serve as a biomarker in diverse disease states. Several new intrinsic anti-oxidative or pro-oxidative factors have recently been reported, and are potential new targets. In the present review, we focus on diabetes, pulmonary hypertension, and renal dysfunction, and their relation with new targets - adrenomedullin, oxidized LDL, and mineralocorticoid receptor.
氧化应激在多种病理状况中起关键作用，包括高血压、肺动脉高压、糖尿病和慢性肾脏病，在心脏、胰腺、肾脏和肺等靶器官中存在高水平的氧化应激。已知氧化应激会激活多种细胞内信号传导，诱导细胞凋亡或细胞过度生长，导致器官功能障碍。因此，针对氧化应激被认为对预防器官损伤有效，并且测量氧化应激状态可作为多种疾病状态下的生物标志物。最近报道了几种新的内源性抗氧化或促氧化因子，它们是潜在的新靶点。在本综述中，我们重点关注糖尿病、肺动脉高压和肾功能不全，以及它们与新靶点——肾上腺髓质素、氧化型低密度脂蛋白和盐皮质激素受体的关系。
