神经母细胞瘤细胞系中L-myc和N-myc癌基因的共扩增。
Coamplification of the L-myc and N-myc oncogenes in a neuroblastoma cell line.
作者信息
Jinbo T, Iwamura Y, Kaneko M, Sawaguchi S
机构信息
Department of Pediatric Surgery, University of Tsukuba, Ibaraki.
出版信息
Jpn J Cancer Res. 1989 Apr;80(4):299-301. doi: 10.1111/j.1349-7006.1989.tb02309.x.
Abstract
The L-myc, N-myc and c-myc genes are members of the myc oncogene family. In particular, L-myc is novel, and amplification of L-myc is still unknown except in small cell lung carcinoma. We examined L-myc amplification in 30 human neuroblastomas using Southern blot hybridization, and found that the L-myc gene was amplified approximately 5-fold in GOTO, a human neuroblastoma cell line. The N-myc gene was also amplified approximately 60-fold and furthermore, over-expression of L-myc and N-myc genes was observed in this cell line. In this report, we describe the coamplification of the myc gene family in the GOTO neuroblastoma cell line.
摘要
L-myc、N-myc和c-myc基因是myc癌基因家族的成员。特别是，L-myc是新发现的，除在小细胞肺癌中外，L-myc的扩增情况仍不明确。我们使用Southern印迹杂交法检测了30例人类神经母细胞瘤中的L-myc扩增情况，发现L-myc基因在人类神经母细胞瘤细胞系GOTO中扩增了约5倍。N-myc基因也扩增了约60倍，此外，在该细胞系中还观察到L-myc和N-myc基因的过表达。在本报告中，我们描述了GOTO神经母细胞瘤细胞系中myc基因家族的共扩增情况。
相似文献
1
Coamplification of the L-myc and N-myc oncogenes in a neuroblastoma cell line.神经母细胞瘤细胞系中L-myc和N-myc癌基因的共扩增。
Jpn J Cancer Res. 1989 Apr;80(4):299-301. doi: 10.1111/j.1349-7006.1989.tb02309.x.
2
3
Inverse correlation between expression of multidrug resistance gene and N-myc oncogene in human neuroblastomas.人神经母细胞瘤中多药耐药基因表达与N-myc癌基因之间的负相关。
Cancer Res. 1990 May 15;50(10):3043-7.
4
Sequence of a germ-line N-myc gene and amplification as a mechanism of activation.生殖系N-myc基因序列及作为激活机制的扩增
Oncogene. 1988 Apr;2(4):399-402.
5
[Amplification of N-myc in neuroblastoma: paradigm for clinical use of an oncogene alteration].
Klin Padiatr. 1990 Jul-Aug;202(4):197-201. doi: 10.1055/s-2007-1025519.
6
Specific expression of the ret proto-oncogene in human neuroblastoma cell lines.原癌基因ret在人神经母细胞瘤细胞系中的特异性表达。
Oncogene. 1990 Sep;5(9):1291-6.
7
Expression of neuronal src mRNA as a favorable marker and inverse correlation to N-myc gene amplification in human neuroblastomas.
Int J Cancer. 1994 Sep 15;58(6):793-8. doi: 10.1002/ijc.2910580607.
8
Genetic clinical markers of human neuroblastoma with special reference to N-myc oncogene: amplified or not amplified?--An overview.
Tumour Biol. 1996;17(2):65-74. doi: 10.1159/000217968.
9
myc gene amplification and expression in primary human neuroblastoma.原代人神经母细胞瘤中myc基因的扩增与表达
Cancer Res. 1990 Mar 1;50(5):1459-63.
10
Detection of N-myc gene amplification by fluorescence in situ hybridization. Diagnostic utility for neuroblastoma.通过荧光原位杂交检测N-myc基因扩增。对神经母细胞瘤的诊断效用。
Am J Pathol. 1993 May;142(5):1339-46.
引用本文的文献
1
MYC-family protein overexpression and prominent nucleolar formation represent prognostic indicators and potential therapeutic targets for aggressive high-MKI neuroblastomas: a report from the children's oncology group.MYC家族蛋白过表达和显著核仁形成是侵袭性高MKI神经母细胞瘤的预后指标和潜在治疗靶点：来自儿童肿瘤学组的报告
Oncotarget. 2017 Dec 15;9(5):6416-6432. doi: 10.18632/oncotarget.23740. eCollection 2018 Jan 19.
2
Autoantibody signature differentiates Wilms tumor patients from neuroblastoma patients.自身抗体特征可区分威尔姆斯瘤患者和神经母细胞瘤患者。
PLoS One. 2011;6(12):e28951. doi: 10.1371/journal.pone.0028951. Epub 2011 Dec 16.
3
The connections between neural crest development and neuroblastoma.神经嵴发育与神经母细胞瘤之间的联系。
Curr Top Dev Biol. 2011;94:77-127. doi: 10.1016/B978-0-12-380916-2.00004-8.
4
Molecular characterization of the in vivo alkylating agent resistant murine EMT-6 mammary carcinoma tumors.体内对烷化剂耐药的小鼠EMT-6乳腺癌肿瘤的分子特征分析
Cancer Chemother Pharmacol. 1995;35(5):423-31. doi: 10.1007/s002800050257.
5
Co-amplification of c-myc and c-erbB-2 oncogenes in a poorly differentiated human gastric cancer.在低分化人胃癌中c-myc和c-erbB-2癌基因的共扩增
Jpn J Cancer Res. 1989 Oct;80(10):920-3. doi: 10.1111/j.1349-7006.1989.tb01626.x.
本文引用的文献
1
Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour.人类神经母细胞瘤细胞系和一个神经母细胞瘤肿瘤中存在与myc细胞癌基因同源性有限的扩增DNA。
Nature. 1983;305(5931):245-8. doi: 10.1038/305245a0.
2
Expression and amplification of the N-myc gene in primary retinoblastoma.N-myc基因在原发性视网膜母细胞瘤中的表达与扩增
Nature. 1984;309(5967):458-60. doi: 10.1038/309458a0.
3
Chromosome localization in normal human cells and neuroblastomas of a gene related to c-myc.与c-myc相关基因在正常人细胞和成神经细胞瘤中的染色体定位。
Nature. 1984;308(5956):288-91. doi: 10.1038/308288a0.
4
The molecular genetics of cellular oncogenes.细胞癌基因的分子遗传学
Annu Rev Genet. 1984;18:553-612. doi: 10.1146/annurev.ge.18.120184.003005.
5
Transposition and amplification of oncogene-related sequences in human neuroblastomas.人类神经母细胞瘤中癌基因相关序列的转位与扩增。
Cell. 1983 Dec;35(2 Pt 1):359-67. doi: 10.1016/0092-8674(83)90169-1.
6
Transcriptionally active c-myc oncogene is contained within NIARD, a DNA sequence associated with chromosome translocations in B-cell neoplasia.转录活性c-myc癌基因包含在NIARD中，NIARD是一种与B细胞肿瘤形成中的染色体易位相关的DNA序列。
Proc Natl Acad Sci U S A. 1983 Jan;80(2):519-23. doi: 10.1073/pnas.80.2.519.
7
Alterations of myc, myb, and rasHa proto-oncogenes in cancers are frequent and show clinical correlation.癌症中myc、myb和rasHa原癌基因的改变很常见，并显示出临床相关性。
Science. 1986 Jan 17;231(4735):261-5. doi: 10.1126/science.3941898.
8
Coamplification of the hst-1 and int-2 genes in human cancers.人类癌症中hst-1和int-2基因的共扩增。
Jpn J Cancer Res. 1988 Apr;79(4):428-32. doi: 10.1111/j.1349-7006.1988.tb01609.x.
9
L-myc, a new myc-related gene amplified and expressed in human small cell lung cancer.L-myc，一种在人类小细胞肺癌中扩增并表达的新的与myc相关的基因。
Nature. 1985;318(6041):69-73. doi: 10.1038/318069a0.
10
No correlation between L-myc restriction fragment length polymorphism and malignancy of human colorectal cancers.L-myc 限制性片段长度多态性与人类结直肠癌恶性程度之间无相关性。
Jpn J Cancer Res. 1988 Jun;79(6):674-6. doi: 10.1111/j.1349-7006.1988.tb02220.x.
Zotero 插件