内皮素增强生长因子刺激的瑞士3T3细胞中的DNA合成。
Endothelin potentiates growth factor-stimulated DNA synthesis in Swiss 3T3 cells.
作者信息
Kusuhara M, Yamaguchi K, Ohnishi A, Abe K, Kimura S, Oono H, Hori S, Nakamura Y
机构信息
Growth Factor Division, National Cancer Center Research Institute, Tokyo.
出版信息
Jpn J Cancer Res. 1989 Apr;80(4):302-5. doi: 10.1111/j.1349-7006.1989.tb02310.x.
Abstract
A murine cell line, Swiss 3T3, is commonly used for the study of cellular growth. The present study revealed that this cell line possesses high-affinity receptors for endothelin, a vasoactive peptide derived from vascular endothelial cells. In this cell line, endothelin potentiated DNA synthesis stimulated by platelet-derived growth factor, basic fibroblast growth factor or insulin. The endothelin concentration required for potentiating DNA synthesis in this cell line is almost the same as that reported previously in endothelin-induced vasoconstriction. Since endothelin increased intracellular calcium levels, this ion may participate in the signal transduction pathways by which endothelin induces potentiation of DNA synthesis.
摘要
一种小鼠细胞系，即瑞士3T3细胞系，常用于细胞生长研究。本研究表明，该细胞系拥有内皮素的高亲和力受体，内皮素是一种源自血管内皮细胞的血管活性肽。在该细胞系中，内皮素增强了由血小板衍生生长因子、碱性成纤维细胞生长因子或胰岛素刺激的DNA合成。在该细胞系中增强DNA合成所需的内皮素浓度与先前报道的内皮素诱导血管收缩的浓度几乎相同。由于内皮素增加了细胞内钙水平，该离子可能参与了内皮素诱导DNA合成增强的信号转导途径。
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本文引用的文献
1
Preparation of iodine-131 labelled human growth hormone of high specific activity.高比活度碘-131标记人生长激素的制备
Nature. 1962 May 5;194:495-6. doi: 10.1038/194495a0.
2
Heterogeneous behavior of the canine arterial and venous wall. Importance of the endothelium.犬动脉和静脉壁的异质性行为。内皮的重要性。
Circ Res. 1982 Oct;51(4):439-47. doi: 10.1161/01.res.51.4.439.
3
Specific receptors for platelet-derived growth factor on cells derived from connective tissue and glia.结缔组织和神经胶质细胞来源的细胞上血小板衍生生长因子的特异性受体。
Proc Natl Acad Sci U S A. 1981 Jun;78(6):3664-8. doi: 10.1073/pnas.78.6.3664.
4
Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate.1,4,5-三磷酸肌醇促使胰腺腺泡细胞非线粒体胞内钙库释放钙离子。
Nature. 1983;306(5938):67-9. doi: 10.1038/306067a0.
5
Role of endothelium in responses of vascular smooth muscle.内皮细胞在血管平滑肌反应中的作用。
Circ Res. 1983 Nov;53(5):557-73. doi: 10.1161/01.res.53.5.557.
6
A new generation of Ca2+ indicators with greatly improved fluorescence properties.新一代具有大大改善的荧光特性的钙离子指示剂。
J Biol Chem. 1985 Mar 25;260(6):3440-50.
7
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FEBS Lett. 1988 Apr 25;231(2):440-4. doi: 10.1016/0014-5793(88)80867-6.
8
Endothelin stimulates c-fos and c-myc expression and proliferation of vascular smooth muscle cells.内皮素刺激血管平滑肌细胞中c-fos和c-myc的表达以及增殖。
FEBS Lett. 1988 Oct 10;238(2):249-52. doi: 10.1016/0014-5793(88)80489-7.
9
Structure-activity relationships of endothelin: importance of the C-terminal moiety.内皮素的构效关系：C末端部分的重要性。
Biochem Biophys Res Commun. 1988 Nov 15;156(3):1182-6. doi: 10.1016/s0006-291x(88)80757-5.
10
Primary structure, synthesis, and biological activity of rat endothelin, an endothelium-derived vasoconstrictor peptide.大鼠内皮素（一种内皮源性血管收缩肽）的一级结构、合成及生物活性
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