内皮素刺激瑞士3T3细胞中的DNA合成。与多肽生长因子的协同作用。
Endothelin stimulates DNA synthesis in Swiss 3T3 cells. Synergy with polypeptide growth factors.
作者信息
Brown K D, Littlewood C J
机构信息
Department of Biochemistry, AFRC Institute of Animal Physiology, Cambridge, U.K.
出版信息
Biochem J. 1989 Nov 1;263(3):977-80. doi: 10.1042/bj2630977.
Abstract
The vasoactive peptide endothelin is shown to be a potent mitogen for Swiss 3T3 cells. Although endothelin has little effect on DNA synthesis when added alone to cells in serum-free medium, the peptide synergizes very strongly with several other growth factors. A half-maximal response to endothelin is observed at approx. 0.3 nM, with a maximal effect at 3 nM. Over the same concentration range, endothelin stimulates a 2-fold increase in the accumulation of cellular inositol phosphates. Endothelin may prove to be a useful additional agonist for studying the signalling pathways involved in the control of 3T3-cell proliferation.
摘要
血管活性肽内皮素被证明是瑞士3T3细胞的一种强效促有丝分裂原。尽管在无血清培养基中单独添加内皮素时对DNA合成几乎没有影响，但该肽与其他几种生长因子具有很强的协同作用。在内皮素浓度约为0.3 nM时观察到半数最大反应，3 nM时达到最大效应。在相同浓度范围内，内皮素可刺激细胞肌醇磷酸积累增加2倍。内皮素可能被证明是研究参与3T3细胞增殖控制的信号通路的一种有用的额外激动剂。
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