Liu Zhengtao, Que Shuping, Xu Jing, Peng Tao
1. Department of Hepatobiliary Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Province, China.
2. Department of Pediatrics, Women and children's hospital of Guangxi, Nanning, 530005, Guangxi province, China.
Int J Med Sci. 2014 Jun 26;11(9):925-35. doi: 10.7150/ijms.8951. eCollection 2014.
Measurement of serum alanine aminotransferase (ALT) is a common, readily available, and inexpensive laboratory assay in clinical practice. ALT activity is not only measured to detect liver disease, but also to monitor overall health. ALT activity is influenced by various factors, including viral hepatitis, alcohol consumption, and medication. Recently, the impact of metabolic abnormalities on ALT variation has raised concern due to the worldwide obesity epidemic. The normal ranges for ALT have been updated and validated considering the metabolic covariates in the various ethnic districts. The interaction between metabolic and demographic factors on ALT variation has also been discussed in previous studies. In addition, an extremely low ALT value might reflect the process of aging, and frailty in older adults has been raised as another clinically significant feature of this enzyme, to be followed with additional epidemiologic investigation. Timely updated, comprehensive, and systematic introduction of ALT activity is necessary to aid clinicians make better use of this enzyme.
血清丙氨酸氨基转移酶（ALT）的检测是临床实践中一种常见、易于获得且成本低廉的实验室检测方法。检测ALT活性不仅用于检测肝脏疾病，还用于监测整体健康状况。ALT活性受多种因素影响，包括病毒性肝炎、饮酒和药物。最近，由于全球肥胖流行，代谢异常对ALT变化的影响引起了关注。考虑到不同种族地区的代谢协变量，ALT的正常范围已得到更新和验证。先前的研究也讨论了代谢和人口统计学因素对ALT变化的相互作用。此外，极低的ALT值可能反映衰老过程，老年人的虚弱已被提出作为该酶的另一个临床显著特征，有待进一步的流行病学调查。及时更新、全面且系统地介绍ALT活性对于帮助临床医生更好地利用该酶是必要的。
