Department of Hepatology, First Hospital, Jilin University, Changchun 130021, China.
Int J Med Sci. 2011 Mar 25;8(3):254-62. doi: 10.7150/ijms.8.254.
Serum biochemical liver tests (LTs) (alanine aminotransferase, aspartate aminotransferase, and gamma glutamyltransferase) and platelet counts are often used to screen for chronic liver disease. We determined the prevalence and etiologies of abnormal LTs in an adult population in Jilin, China.
A total of 3791 individuals between the ages of 18 and 79 years were interviewed and then underwent ultrasonography and blood tests.
The prevalence of abnormal LTs was 14.77% (560 out of 3791 subjects). The risk factors for abnormal LTs were non-alcoholic fatty liver disease (NAFLD) alone, which accounted for 11.61%, metabolic syndrome alone for 25%, or both for 22.14%. Abnormal LTs were more common in male than in female subjects. The development of abnormal LTs was correlated with older age males, increased daily alcohol intake, poor quality of sleep, smoking, fasting plasma glucose, body mass index, triglyceridemia, and low-density lipoprotein. Abnormal LTs in patients with metabolic syndrome and NAFLD were associated with high fasting plasma glucose, triglycerides, body mass index, low density lipoprotein, male, young age, poor sleep quality, smoking, and alcohol intake. However, abnormal LTs in patients with hepatitis B virus were associated with gender and increased age.
The results from the current study demonstrated that the prevalence of abnormal LTs is high in the population (14.77%). Metabolic syndrome, NAFLD, and alcohol intake appear to be potentially important causes of the observed abnormal LTs.
血清生化肝试验（LTs）（丙氨酸氨基转移酶、天冬氨酸氨基转移酶和γ-谷氨酰转移酶）和血小板计数常用于筛查慢性肝病。我们确定了中国吉林一个成年人人群中异常 LTs 的流行率和病因。
共对 3791 名年龄在 18 至 79 岁之间的个体进行了访谈，然后进行了超声检查和血液检查。
异常 LTs 的患病率为 14.77%（560/3791 例）。异常 LTs 的危险因素是单纯性非酒精性脂肪性肝病（NAFLD）占 11.61%，单纯代谢综合征占 25%，或两者兼占 22.14%。异常 LTs 在男性中比在女性中更为常见。异常 LTs 的发生与年龄较大的男性、每日饮酒量增加、睡眠质量差、吸烟、空腹血糖、体重指数、甘油三酯和低密度脂蛋白有关。代谢综合征和 NAFLD 患者的异常 LTs 与空腹血糖升高、甘油三酯升高、体重指数升高、低密度脂蛋白升高、男性、年轻、睡眠质量差、吸烟和饮酒有关。然而，乙型肝炎病毒患者的异常 LTs 与性别和年龄增长有关。
本研究结果表明，人群中异常 LTs 的患病率较高（14.77%）。代谢综合征、NAFLD 和饮酒可能是导致观察到的异常 LTs 的潜在重要原因。
