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鼻咽癌合并肺结核和痛风的治疗：一例报告。

Treatment of nasopharyngeal carcinoma with pulmonary tuberculosis and gout: A case report.

作者信息

Wu Lu, Li Mei, Liu Dingyi, Jiang Ming, Liu Yanyang, Li Zhixi, Wang Xia, Yu Yang, Luo Feng

机构信息

Department of Medical Oncology, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, P.R. China.

Department of Oncology, Chengdu Seventh People's Hospital, Chengdu, Sichuan 610041, P.R. China.

出版信息

Oncol Lett. 2014 Aug;8(2):753-757. doi: 10.3892/ol.2014.2180. Epub 2014 May 26.

DOI:10.3892/ol.2014.2180
PMID:25013497
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4081372/
Abstract

In China, the incidence of nasopharyngeal carcinoma (NPC) and tuberculosis remains high. Additionally, there has been a marked increase in the prevalence of gout. In recent years, there has been an increase in the number of co-existing diseases. To the best of our knowledge, there have been no previous cases reported in the literature with regard to patients suffering from NPC complicated with pulmonary tuberculosis and gout. The present study describes the case of a 59-year-old male with this condition. The patient received a combination of anti-tumor, anti-tuberculosis and anti-gout therapies, and experienced no severe adverse reactions during treatment. At present, the patient's Eastern Cooperative Oncology Group performance status is good, there has been no local recurrence or distant metastasis of the NPC, and the pulmonary tuberculosis and gout are well controlled. The aim of this study was to provide insight into the treatment of patients suffering from co-existing conditions.

摘要

在中国，鼻咽癌（NPC）和结核病的发病率仍然很高。此外，痛风的患病率显著上升。近年来，合并疾病的数量有所增加。据我们所知，此前文献中尚未报道过鼻咽癌合并肺结核和痛风的患者病例。本研究描述了一名患有这种疾病的59岁男性的病例。该患者接受了抗肿瘤、抗结核和抗痛风联合治疗，治疗期间未出现严重不良反应。目前，该患者的东部肿瘤协作组体能状态良好，鼻咽癌无局部复发或远处转移，肺结核和痛风得到良好控制。本研究的目的是为患有合并疾病的患者的治疗提供见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3078/4081372/432aa806638d/OL-08-02-0753-g08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3078/4081372/23285101c7df/OL-08-02-0753-g00.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3078/4081372/a2b23fffdc75/OL-08-02-0753-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3078/4081372/a391ca02bc5e/OL-08-02-0753-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3078/4081372/18ad03a63e92/OL-08-02-0753-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3078/4081372/9ba3cd04d772/OL-08-02-0753-g07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3078/4081372/432aa806638d/OL-08-02-0753-g08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3078/4081372/23285101c7df/OL-08-02-0753-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3078/4081372/715c636c2241/OL-08-02-0753-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3078/4081372/8820840a8beb/OL-08-02-0753-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3078/4081372/0e5d0d3eb45e/OL-08-02-0753-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3078/4081372/a2b23fffdc75/OL-08-02-0753-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3078/4081372/a391ca02bc5e/OL-08-02-0753-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3078/4081372/18ad03a63e92/OL-08-02-0753-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3078/4081372/9ba3cd04d772/OL-08-02-0753-g07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3078/4081372/432aa806638d/OL-08-02-0753-g08.jpg

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本文引用的文献

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Anticancer Res. 2012 Feb;32(2):681-6.
2
Epidemiology of eight common rheumatic diseases in China: a large-scale cross-sectional survey in Beijing.中国八种常见风湿病的流行病学：北京的一项大规模横断面调查。
Rheumatology (Oxford). 2012 Apr;51(4):721-9. doi: 10.1093/rheumatology/ker370. Epub 2011 Dec 16.
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Addition of bevacizumab to standard chemoradiation for locoregionally advanced nasopharyngeal carcinoma (RTOG 0615): a phase 2 multi-institutional trial.
添加贝伐珠单抗到标准放化疗治疗局部晚期鼻咽癌（RTOG 0615）：一项 2 期多机构试验。
Lancet Oncol. 2012 Feb;13(2):172-80. doi: 10.1016/S1470-2045(11)70303-5. Epub 2011 Dec 15.
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Recommendations for use of an isoniazid-rifapentine regimen with direct observation to treat latent Mycobacterium tuberculosis infection.推荐使用异烟肼-利福平方案，并进行直接观察，以治疗潜伏性结核分枝杆菌感染。
MMWR Morb Mortal Wkly Rep. 2011 Dec 9;60(48):1650-3.
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Three months of rifapentine and isoniazid for latent tuberculosis infection.利福喷丁和异烟肼治疗潜伏性结核感染 3 个月。
N Engl J Med. 2011 Dec 8;365(23):2155-66. doi: 10.1056/NEJMoa1104875.
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Ancient migration routes of Austronesian-speaking populations in oceanic Southeast Asia and Melanesia might mimic the spread of nasopharyngeal carcinoma.南岛语族人群在东南亚海洋地区和美拉尼西亚的古代迁徙路线可能与鼻咽癌的传播相似。
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