Ovanez Christopher, Crawford Joel, Asarian Armand, Xiao Philip
Department of Pathology and Laboratory Medicine, The Brooklyn Hospital Center, Brooklyn, NY, USA.
Department of Surgery, The Brooklyn Hospital Center, Brooklyn, NY, USA.
J Surg Case Rep. 2014 Jul 11;2014(7):rju063. doi: 10.1093/jscr/rju063.
Invasive ductal carcinoma of the breast with clear cell changes is a very rare pathological entity. There are <150 cases of this breast cancer subtype reported in the literature. Clear cell carcinoma could be easily missed or under-diagnosed in a breast core biopsy specimen due to the fact that this subtype tends to show a papillary pattern with clear cell and pseudo-lactating changes, especially in young female patients. Normal breast tissue may possess clear cells as a consequence of the physiological changes of pregnancy, the clearing of the cytoplasm within myoepithelial cells, or the clearing of the cytoplasm in apocrine metaplasia. Owing to its aggressive clinical course, clear cell carcinoma must be differentiated from other subtypes of breast carcinoma. Special attention given to this rare subtype by pathologists and clinicians could avoid misdiagnosis and delay of treatment.
伴有透明细胞改变的乳腺浸润性导管癌是一种非常罕见的病理实体。文献报道的这种乳腺癌亚型病例不足150例。在乳腺粗针穿刺活检标本中，透明细胞癌很容易被漏诊或诊断不足，因为该亚型往往呈现出伴有透明细胞和假泌乳改变的乳头状模式，尤其是在年轻女性患者中。正常乳腺组织可能由于妊娠的生理变化、肌上皮细胞内细胞质的清除或大汗腺化生中细胞质的清除而含有透明细胞。由于其侵袭性的临床病程，透明细胞癌必须与其他乳腺癌亚型相鉴别。病理学家和临床医生对这种罕见亚型给予特别关注可以避免误诊和治疗延误。
