Lo C W, Walker W A
Nutr Rev. 1989 Jul;47(7):193-8. doi: 10.1111/j.1753-4887.1989.tb02837.x.
Intestinal adaptation, in terms of increasing intestinal length and weight, usually occurs rapidly after small-bowel resection. However, this response depends on provision of enteral nutrients. If total parenteral nutrition without enteral feeding is prolonged, hypoplasia of the intestinal mucosa results. Adaptation is probably mediated through the presence of luminal nutrients, particularly glutamine, which is preferentially used by the intestine. However, systemic hormonal factors, possibly gastrin, cholecystokinin, and glucagon, also influence intestinal adaptation. Thus, in the management of short-bowel syndromes, enteral nutrition should be added to total parenteral nutrition as soon as possible.
就小肠长度和重量增加而言，肠道适应通常在小肠切除术后迅速发生。然而，这种反应取决于肠内营养的提供。如果长期进行完全胃肠外营养而不给予肠内喂养，会导致肠黏膜发育不全。适应可能是通过肠腔内营养物质的存在介导的，特别是谷氨酰胺，肠道优先利用谷氨酰胺。然而，全身性激素因素，可能是胃泌素、胆囊收缩素和胰高血糖素，也会影响肠道适应。因此，在短肠综合征的管理中，应尽快在完全胃肠外营养中添加肠内营养。
