Jones T Bucky
Department of Anatomy, Arizona College of Medicine, Midwestern University, Glendale, AZ, USA.
Exp Neurol. 2014 Aug;258:78-90. doi: 10.1016/j.expneurol.2014.03.003.
Over the past 15 years an immense amount of data has accumulated regarding the infiltration and activation of lymphocytes in the traumatized spinal cord. Although the impact of the intraspinal accumulation of lymphocytes is still unclear, modulation of the adaptive immune response via active and passive vaccination is being evaluated for its preclinical efficacy in improving the outcome for spinal-injured individuals. The complexity of the interaction between the nervous and the immune systems is highlighted in the contradictions that appear in response to these modulations. Current evidence regarding augmentation and inhibition of the adaptive immune response to spinal cord injury is reviewed with an aim toward reconciling conflicting data and providing consensus issues that may be exploited in future therapies. Opportunities such an approach may provide are highlighted as well as the obstacles that must be overcome before such approaches can be translated into clinical trials.
在过去15年里，已经积累了大量关于创伤性脊髓中淋巴细胞浸润和激活的数据。尽管脊髓内淋巴细胞积聚的影响仍不明确，但通过主动和被动疫苗接种对适应性免疫反应进行调节的临床前疗效正在评估中，以改善脊髓损伤患者的预后。神经系统和免疫系统之间相互作用的复杂性在对这些调节的反应中出现的矛盾中凸显出来。本文综述了目前关于增强和抑制脊髓损伤适应性免疫反应的证据，旨在调和相互矛盾的数据，并提供可能在未来治疗中利用的共识问题。强调了这种方法可能提供的机会以及在将这种方法转化为临床试验之前必须克服的障碍。
