Yin Jun, Wang Liming, Tang Weifeng, Wang Xu, Lv Lu, Shao Aizhong, Shi Yijun, Ding Guowen, Chen Suocheng, Gu Haiyong
Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University, Zhenjiang, China.
Cancer institute, Department of Chemotherapy, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu, China.
PLoS One. 2014 Jul 14;9(7):e101705. doi: 10.1371/journal.pone.0101705. eCollection 2014.
Esophageal cancer remains the sixth leading cause of cancer associated death and eighth most common cancer worldwide. Genetic factors, such as single nucleotide polymorphisms (SNPs), may contribute to the carcinogenesis of esophageal cancer. Here, we conducted a hospital based case-control study to evaluate the genetic susceptibility of functional SNPs on the development of esophageal cancer. A total of 629 esophageal squamous cell carcinoma (ESCC) cases and 686 controls were enrolled for this study. The OPG rs3102735 T>C, rs2073618 G>C, RANK rs1805034 T>C, RANKL rs9533156 T>C and rs2277438 A>G were determined by ligation detection reaction method. Our findings suggested that RANK rs1805034 T>C is associated with the susceptibility of ESCC, which is more evident in male and elder (≥63) patients. Our study provides the first evidence that functional polymorphisms RANK rs1805034 T>C may be an indicator for individual susceptibility to ESCC. However, further larger studies among different ethnic populations are warranted to verify our conclusion.
食管癌仍然是全球第六大癌症相关死亡原因和第八大常见癌症。遗传因素，如单核苷酸多态性（SNP），可能与食管癌的致癌作用有关。在此，我们进行了一项基于医院的病例对照研究，以评估功能性SNP对食管癌发生发展的遗传易感性。本研究共纳入629例食管鳞状细胞癌（ESCC）病例和686例对照。通过连接检测反应法测定了OPG rs3102735 T>C、rs2073618 G>C、RANK rs1805034 T>C、RANKL rs9533156 T>C和rs2277438 A>G。我们的研究结果表明，RANK rs1805034 T>C与ESCC的易感性相关，在男性和年龄较大（≥63岁）的患者中更为明显。我们的研究首次提供了证据，表明功能性多态性RANK rs1805034 T>C可能是个体对ESCC易感性的一个指标。然而，需要在不同种族人群中进行进一步的大规模研究来验证我们的结论。
