Jin Zi-Yi, Wu Ming, Han Ren-Qiang, Zhang Xiao-Feng, Wang Xu-Shan, Liu Ai-Ming, Zhou Jin-Yi, Lu Qing-Yi, Kim Claire H, Mu Lina, Zhang Zuo-Feng, Zhao Jin-Kou
Department of Non-communicable Chronic Disease Control, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, Jiangsu, China; Jiangyin Center for Disease Control and Prevention, Jiangyin, Jiangsu, China.
Department of Non-communicable Chronic Disease Control, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, Jiangsu, China.
PLoS One. 2014 Jul 14;9(7):e102685. doi: 10.1371/journal.pone.0102685. eCollection 2014.
Although the International Agency for Research on Cancer (IARC) has classified various indoor air pollutants as carcinogenic to humans, few studies evaluated the role of household ventilation in reducing the impact of indoor air pollutants on lung cancer risk.
To explore the association between household ventilation and lung cancer.
A population-based case-control study was conducted in a Chinese population from 2003 to 2010. Epidemiologic and household ventilation data were collected using a standardized questionnaire. Unconditional logistic regression was employed to estimate adjusted odds ratios (ORadj) and their 95% confidence intervals (CI).
Among 1,424 lung cancer cases and 4,543 healthy controls, inverse associations were observed for good ventilation in the kitchen (ORadj = 0.86, 95% CI: 0.75, 0.98), bedroom (ORadj = 0.90, 95% CI: 0.79, 1.03), and both kitchen and bedroom (ORadj = 0.87, 95% CI: 0.75, 1.00). Stratified analyses showed lung cancer inversely associated with good ventilation among active smokers (ORadj = 0.85, 95% CI: 0.72, 1.00), secondhand smokers at home (ORadj = 0.77, 95% CI: 0.63, 0.94), and those exposed to high-temperature cooking oil fumes (ORadj = 0.82, 95% CI: 0.68, 0.99). Additive interactions were found between household ventilation and secondhand smoke at home as well as number of household pollutant sources.
A protective association was observed between good ventilation of households and lung cancer, most likely through the reduction of exposure to indoor air pollutants, indicating ventilation may serve as one of the preventive measures for lung cancer, in addition to tobacco cessation.
尽管国际癌症研究机构（IARC）已将多种室内空气污染物归类为对人类致癌，但很少有研究评估家庭通风在降低室内空气污染物对肺癌风险影响方面的作用。
探讨家庭通风与肺癌之间的关联。
2003年至2010年在中国人群中进行了一项基于人群的病例对照研究。使用标准化问卷收集流行病学和家庭通风数据。采用无条件逻辑回归来估计调整后的比值比（ORadj）及其95%置信区间（CI）。
在1424例肺癌病例和4543例健康对照中，观察到厨房良好通风（ORadj = 0.86，95% CI：0.75，0.98）、卧室良好通风（ORadj = 0.90，95% CI：0.79，1.03）以及厨房和卧室均良好通风（ORadj = 0.87，95% CI：0.75，1.00）存在负相关。分层分析显示，肺癌与现吸烟者（ORadj = 0.85，95% CI：0.72，1.00）、家中二手吸烟者（ORadj = 0.77，95% CI：0.63，0.94）以及接触高温烹饪油烟者（ORadj = 0.82，95% CI：0.68，0.99）的良好通风呈负相关。发现家庭通风与家中二手烟以及家庭污染物源数量之间存在相加交互作用。
观察到家庭良好通风与肺癌之间存在保护关联，很可能是通过减少室内空气污染物暴露实现的，这表明除戒烟外，通风可能作为肺癌的预防措施之一。
