Kusche J, Mennigen R, Leisten L
II. Department of Surgery of the University of Cologne, FRG.
Agents Actions. 1989 Apr;27(1-2):218-20. doi: 10.1007/BF02222244.
Some mutagenic hydrazino compounds are also diamine oxidase inhibitors. Therefore, this interrelationship was studied for the intestinal carcinogen azoxymethane. In vitro, azoxymethane was a very weak inhibitor of rat intestinal diamine oxidase activity. In vivo, after subcutaneous injection of a single dose of azoxymethane, diamine oxidase activity was increased in the duodenum but was mainly inhibited in the colon. Intestinal diamine oxidase activity may then be influenced by regulatory processes induced by azoxymethane rather than by a direct effect.
一些具有致突变性的肼基化合物也是二胺氧化酶抑制剂。因此，针对肠道致癌物偶氮甲烷对这种相互关系进行了研究。在体外，偶氮甲烷是大鼠肠道二胺氧化酶活性的一种非常弱的抑制剂。在体内，皮下注射单剂量的偶氮甲烷后，十二指肠中的二胺氧化酶活性增加，但在结肠中主要受到抑制。肠道二胺氧化酶活性可能受偶氮甲烷诱导的调节过程影响，而非直接作用。
