Olubuyide I O, Bristol J B, Williamson R C
Br J Cancer. 1985 Mar;51(3):383-8. doi: 10.1038/bjc.1985.51.
Numbers of intestinal goblet cells containing specific acid mucins were determined in male Sprague-Dawley rats receiving azoxymethane (total dose 90 mg kg-1) with or without jejunoileal bypass (JIB). Controls had injections of vehicle and sham bypass. Thirty weeks postoperatively colorectal length and crypt depth were increased by azoxymethane and further increased by JIB. JIB doubled the yield of intestinal tumours (P less than 0.01). Goblet cells containing sulphomucins normally predominated throughout the intestinal tract. Contents of sulphomucins and especially sialomucins were consistently higher in the small bowel and colon of rats receiving azoxymethane alone, but again the highest values were observed in animals with azoxymethane plus JIB. Both small-bowel bypass and azoxymethane stimulate adaptive growth of the colon and small bowel remaining in circuit. Goblet-cell hyperplasia is a feature of this response, and sialomucins are preferentially secreted by the adapting epithelium.
在接受或未接受空肠回肠旁路术（JIB）的雄性斯普拉格-道利大鼠中，测定了含有特定酸性粘蛋白的肠道杯状细胞数量。对照组注射赋形剂并进行假旁路手术。术后30周，结直肠长度和隐窝深度因给予偶氮甲烷而增加，JIB使其进一步增加。JIB使肠道肿瘤的发生率增加了一倍（P<0.01）。含有硫酸粘蛋白的杯状细胞通常在整个肠道中占主导地位。单独接受偶氮甲烷的大鼠小肠和结肠中硫酸粘蛋白尤其是唾液酸粘蛋白的含量始终较高，但同样，在接受偶氮甲烷加JIB的动物中观察到的值最高。小肠旁路术和偶氮甲烷均刺激了回路中剩余结肠和小肠的适应性生长。杯状细胞增生是这种反应的一个特征，适应性上皮优先分泌唾液酸粘蛋白。
