Biegański T, Braun R, Kusche J
Agents Actions. 1984 Apr;14(3-4):351-5. doi: 10.1007/BF01973825.
N-methyl-N-formylhydrazine is the first active intermediate of the poison gyromitrin of the mushroom: false morel. This compound is a non-competitive inhibitor of human intestinal diamine oxidase (ID50 = 1.6 X 10(-5) mol/l). This concentration corresponds to less than 5 g of wet weight of mushroom/l. The diamine oxidases from 5 other sources are inhibited in a similar manner. Semicarbazide and aminoguanidine are 10-respectively 1000-fold more potent inhibitors of the human intestinal diamine oxidase. An involvement of the diamine oxidase inhibitory property of N-methyl-N-formylhydrazine in toxic and mutagenic effects of the substance is considered.
N-甲基-N-甲酰肼是蘑菇（假羊肚菌）中毒素鹿花菌素的首个活性中间体。该化合物是人类肠道二胺氧化酶的非竞争性抑制剂（半数抑制浓度=1.6×10⁻⁵摩尔/升）。此浓度相当于每升蘑菇湿重低于5克。来自其他5个来源的二胺氧化酶也受到类似方式的抑制。氨基脲和氨基胍对人类肠道二胺氧化酶的抑制效力分别强10倍和1000倍。考虑了N-甲基-N-甲酰肼的二胺氧化酶抑制特性在该物质的毒性和诱变作用中的参与情况。
