无机锌与亚铁的肠道吸收

Inorganic zinc and the intestinal absorption of ferrous iron.

作者信息

Crofton R W, Gvozdanovic D, Gvozdanovic S, Khin C C, Brunt P W, Mowat N A, Aggett P J

机构信息

Department of Gastroenterology, Woodend General Hospital, Aberdeen, Scotland.

出版信息

Am J Clin Nutr. 1989 Jul;50(1):141-4. doi: 10.1093/ajcn/50.1.141.

DOI:10.1093/ajcn/50.1.141

PMID:2502004

Abstract

The effect of inorganic zinc on the absorption of inorganic iron (Fe+2) from a solution was assessed in two studies on healthy male volunteers. In the first study coadministration of 344 mumol of zinc had no effect (p less than 0.5) on the absorption of 842 mumol of radiolabeled Fe, assessed by the area under plasma Fe increment time curve during the 3 (AUC3) and 6 (AUC6) h postadministration (Fe alone AUC3 = 176.4 +/- 39.3; AUC6 = 387 +/- 101; Fe + Zn AUC3 = 180 +/- 33.1; AUC6 = 396 +/- 73.1 mumol.h-1.L-1), total plasma content of 59Fe, and whole-body retention of 59Fe. In the second study only the plasma appearance of Fe was monitored. After administration of 421 mumol of Fe alone, the AUC3 and AUC6 were 167 +/- 21.2 and 429.4 +/- 57 mumol.h-1.L-1, respectively; these were reduced to 56.4 +/- 17 and 119 +/- 34 (p less than 0.002) by 421 mumol Zn and further reduced by 1048 mumol Zn to 33 +/- 15 and 43.4 +/- 23.8 mumol.h-1.L-1 (p less than 0.001), respectively. It is concluded that Zn can impair the intestinal absorption of Fe.

摘要

在两项针对健康男性志愿者的研究中，评估了无机锌对溶液中无机铁（Fe²⁺）吸收的影响。在第一项研究中，通过给药后3小时（AUC3）和6小时（AUC6）血浆铁增量时间曲线下的面积评估，344微摩尔锌的共同给药对842微摩尔放射性标记铁的吸收没有影响（p<0.5）（单独铁给药时AUC3 = 176.4±39.3；AUC6 = 387±101；铁+锌给药时AUC3 = 180±33.1；AUC6 = 396±73.1微摩尔·小时⁻¹·升⁻¹）、59Fe的血浆总含量以及59Fe的全身保留率。在第二项研究中，仅监测了铁的血浆出现情况。单独给予421微摩尔铁后，AUC3和AUC6分别为167±21.2和429.4±57微摩尔·小时⁻¹·升⁻¹；421微摩尔锌使其分别降至56.4±17和119±34（p<0.002），1048微摩尔锌进一步使其降至33±15和43.4±23.8微摩尔·小时⁻¹·升⁻¹（p<0.001）。结论是锌会损害铁的肠道吸收。