Baggish M S, Dorsey J H, Adelson M
State University of New York Health Sciences Center, Syracuse.
Am J Obstet Gynecol. 1989 Jul;161(1):60-8. doi: 10.1016/0002-9378(89)90233-0.
Between 1977 and 1987, the CO2 laser was used to treat 4024 women who were diagnosed by cytology studies, colposcopy, and biopsy examination to have cervical intraepithelial neoplasia. On the basis of specific indications, these women were treated by vaporization, excisional conization, or combination conization procedure. The evolution of methodology for each laser technique was based on specific pathophysiology and long-term observation of results. A total of 3070 patients underwent vaporization, 2881 of whom had no evidence of disease after one laser exposure (93.8%). Of the 954 patients who had laser excisional procedures, 925 (97%) had no evidence of disease. The most common complications observed were intraoperative and postoperative bleeding; however, sutures were required in only 1.34% of the latter. The risks of cervical stenosis (1.1%), incompetent cervix (0%), and pelvic infection (0.05%) were very low. This 10-year study demonstrated that the CO2 laser was a highly effective method for treating cervical epithelial neoplasia and had the added benefit of preserving reproductive function and anatomic integrity.
1977年至1987年间，二氧化碳激光被用于治疗4024名经细胞学检查、阴道镜检查和活检确诊为宫颈上皮内瘤变的女性。根据特定指征，这些女性接受了汽化、切除性锥切或联合锥切手术治疗。每种激光技术方法的演变基于特定的病理生理学和对结果的长期观察。共有3070例患者接受了汽化治疗，其中2881例（93.8%）在一次激光治疗后无疾病证据。在954例接受激光切除手术的患者中，925例（97%）无疾病证据。观察到的最常见并发症是术中及术后出血；然而，仅1.34%的后者需要缝合。宫颈狭窄（1.1%）、宫颈机能不全（0%）和盆腔感染（0.05%）的风险非常低。这项为期10年的研究表明，二氧化碳激光是治疗宫颈上皮内瘤变的一种高效方法，并且具有保留生殖功能和解剖完整性的额外益处。
