Rahman Md Mahbubur, Lee Sei-Jin, Mun A-Reum, Adam Gareeballah Osman, Park Ra-Mi, Kim Gi-Beum, Kang Hyung-Sub, Kim Jin-Shang, Kim Shang-Jin, Kim Sung-Zoo
Department of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Chonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do, 561-756, Republic of Korea.
Biol Trace Elem Res. 2014 Oct;161(1):85-90. doi: 10.1007/s12011-014-9983-x. Epub 2014 Jul 19.
Magnesium (Mg) plays a central role in neuronal activity, cardiac excitability, neuromuscular transmission, muscular contraction, vasomotor tone, and blood pressure, all of which are significantly related to physical performance. To date, the available data about detection of blood total Mg (tMg; free-ionized, protein-bound, and anion-complex forms) are inconsistent, and there is limited information on blood free-ionized Mg (Mg(2+)) in relation to physical exercise. The aim of this study was to determine the biochemical changes related to energy metabolism after acute exhaustive swimming exercise (AESE) in rats in an attempt to correlate the role of blood Mg(2+) with metabolites/enzymes related to energy production. After AESE, blood Mg(2+), tMg, K(+), partial pressure of carbon dioxide, lactate, total protein (T-PRO), high-density lipoprotein (HDL), creatinine (CRE), blood urea nitrogen (BUN), uric acid (UA), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alanine phosphatase (ALP), lactate dehydrogenase (LDH), and creatinine kinase (CK) were significantly increased, whereas pH, partial pressure of oxygen, oxygen saturation, the Mg(2+)/tMg and Ca(2+)/Mg(2+) ratios, HCO3 (-), glucose, triglyceride (TG), and low-density lipoprotein (LDL) were significantly decreased. During AESE, lactate, T-PRO, albumin, AST, ALP, LDH, CK, CRE, BUN, and UA showed significant positive correlations with changes in blood Mg(2+), while glucose, TG, and LDL correlated to Mg(2+) in a negative manner. In conclusion, AESE induced increases in both blood Mg(2+) and tMg, accompanied by changes in blood metabolites and enzymes related to energy metabolism due to increased metabolic demands and mechanical damages.
镁（Mg）在神经元活动、心脏兴奋性、神经肌肉传递、肌肉收缩、血管运动张力和血压中起着核心作用，所有这些都与身体机能显著相关。迄今为止，关于血液总镁（tMg；游离离子、蛋白结合和阴离子络合形式）检测的现有数据并不一致，而且关于与体育锻炼相关的血液游离离子镁（Mg(2+)）的信息有限。本研究的目的是确定大鼠急性力竭性游泳运动（AESE）后与能量代谢相关的生化变化，试图将血液Mg(2+)的作用与能量产生相关的代谢物/酶联系起来。AESE后，血液Mg(2+)、tMg、K(+)、二氧化碳分压、乳酸、总蛋白（T-PRO）、高密度脂蛋白（HDL）、肌酐（CRE）、血尿素氮（BUN）、尿酸（UA）、丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）、碱性磷酸酶（ALP）、乳酸脱氢酶（LDH）和肌酸激酶（CK）显著升高，而pH、氧分压、氧饱和度、Mg(2+)/tMg和Ca(2+)/Mg(2+)比值、HCO3 (-)、葡萄糖、甘油三酯（TG）和低密度脂蛋白（LDL）显著降低。在AESE期间，乳酸、T-PRO、白蛋白、AST、ALP、LDH、CK、CRE、BUN和UA与血液Mg(2+)的变化呈显著正相关，而葡萄糖、TG和LDL与Mg(2+)呈负相关。总之，AESE导致血液Mg(2+)和tMg均升高，同时由于代谢需求增加和机械损伤，与能量代谢相关的血液代谢物和酶也发生了变化。
