Mitra Sayantanava, Nizamie S Haque, Goyal Nishant, Tikka Sai Krishna
Department of Psychiatry, Central Institute of Psychiatry, Kanke, Ranchi, Jharkhand, India.
K.S. Mani Centre for Cognitive Neurosciences and Department of Psychiatry, Central Institute of Psychiatry, Kanke, Ranchi, Jharkhand, India.
Indian J Psychol Med. 2014 Jul;36(3):276-81. doi: 10.4103/0253-7176.135380.
The 'mirror-neuron system' is thought to play an important role in automatic decoding of biological motions and interpretation of socially adaptive environmental stimuli. Accordingly, a dysfunction in this system in schizophrenia has been hypothesised to mediate the psychotic manifestations.
As a part of an ongoing study, we evaluated the mirror neuron system using 'EEG mu-wave (8-13 Hz) suppression' paradigm in 15 drug naïve/drug free patients and compared the working to 15 age, sex and education matched controls. We also correlated the psychopathology scores on PANSS with the mu wave suppression in the schizophrenia patients, at baseline. We used high (192-channel) resolution EEG to record the mu rhythm while the subjects watched alternating sequences of a socially-relevant biological motion and white visual-noise on a custom made video-clip.
We found a significant difference in the degree of mu wave suppression between the two groups. We also found that the degree of mu suppression over right sensorimotor cortex at presentation correlated significantly and negatively with thought disorder in the patient group, and had a strong linear relationship.
This study replicates past findings regarding a dysfunctional mirror neuron system in schizophrenia patients, and also emphasizes the role of rMNS in schizophrenic thought disorders.
“镜像神经元系统”被认为在生物运动的自动解码以及对社会适应性环境刺激的解读中发挥重要作用。因此，有假说认为精神分裂症患者该系统的功能障碍介导了精神病性症状。
作为一项正在进行的研究的一部分，我们使用“脑电图μ波（8 - 13赫兹）抑制”范式对15例未用药/未服药的患者的镜像神经元系统进行了评估，并将其与15名年龄、性别和教育程度相匹配的对照者进行比较。我们还在基线时将精神分裂症患者阳性和阴性症状量表（PANSS）上的精神病理学得分与μ波抑制进行了相关性分析。当受试者观看定制视频片段中交替出现的具有社会相关性的生物运动和白色视觉噪声序列时，我们使用高分辨率（192导）脑电图记录μ节律。
我们发现两组之间μ波抑制程度存在显著差异。我们还发现，在呈现时右侧感觉运动皮层的μ波抑制程度与患者组的思维紊乱显著负相关，且呈强线性关系。
本研究重复了过去关于精神分裂症患者镜像神经元系统功能障碍的研究结果，并强调了右侧镜像神经元系统在精神分裂症思维紊乱中的作用。
