谷胱甘肽 S-转移酶 T1 基因缺失型与早产风险的荟萃分析。
Meta-analysis of GSTT1 null genotype and preterm delivery risk.
作者信息
Liu Yi, Tang Yun-Bing, Chen Jie, Huang Zhao-Xia
机构信息
Department of Gynecology and Obstetrics, The Second Affiliated Hospital of Wenzhou Medical University Wenzhou 325000, Zhejiang, China.
出版信息
Int J Clin Exp Med. 2014 Jun 15;7(6):1537-41. eCollection 2014.
Glutathione S-transferase T1 (GSTT1) null genotype has been indicated to be correlated with preterm delivery (PTD) susceptibility, but study results were still debatable. Thus, a meta-analysis was conducted. PubMed, EMBASE, and CNKI were searched. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to calculate the strength of association in the random-effects model or fixed-effects model. Nine case-control studies with a total of 2526 cases and 4565 controls were eligible. The null genotype of GSTT1 was associated with a significantly increased risk of PTD when compared with present genotype (OR = 1.18; 95% CI 1.05-1.33; I(2) = 33). In the subgroup analysis according to ethnicity, significantly increased PTD risk was observed in Asians (OR = 1.20; 95% CI 1.01-1.33; I(2) = 0%) but not in Caucasians (OR = 1.32; 95% CI 0.89-1.97; I(2) = 77). This meta-analysis suggested that GSTT1 null genotype may be associated with the risk of PTD.
谷胱甘肽S-转移酶T1（GSTT1）无效基因型已被指出与早产（PTD）易感性相关，但研究结果仍存在争议。因此，进行了一项荟萃分析。检索了PubMed、EMBASE和中国知网。采用比值比（OR）及95%置信区间（CI）计算随机效应模型或固定效应模型中的关联强度。纳入9项病例对照研究，共2526例病例和4565例对照。与现有基因型相比，GSTT1无效基因型与PTD风险显著增加相关（OR = 1.18；95% CI 1.05 - 1.33；I(2) = 33）。在按种族进行的亚组分析中，亚洲人PTD风险显著增加（OR = 1.20；95% CI 1.01 - 1.33；I(2) = 0%），而高加索人则未观察到（OR = 1.32；95% CI 0.89 - 1.97；I(2) = 77）。这项荟萃分析表明，GSTT1无效基因型可能与PTD风险相关。
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