National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.
Cell. 2014 Jul 17;158(2):237-238. doi: 10.1016/j.cell.2014.07.004.
Epigenetic inheritance of resistance to exogenous nucleic acids via small interfering (si) RNA is well established in animal models. Rechavi et al. demonstrate epigenetic inheritance of a starvation-induced pattern of gene silencing caused by endogenous siRNAs and resulting in an increased longevity in the third generation progeny. Combined with recent findings in prokaryotes, these results suggest that Lamarckian-type inheritance of acquired traits is a major evolutionary phenomenon.
动物模型中已经证实了通过小干扰 (si) RNA 对外源核酸的抗性的表观遗传遗传。Rechavi 等人证明了内源性 siRNA 引起的饥饿诱导的基因沉默模式的表观遗传遗传，并导致第三代后代的寿命延长。结合最近在原核生物中的发现，这些结果表明获得性状的拉马克式遗传是一种主要的进化现象。
