Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA; Department of Microbiology, Cornell University, Ithaca, NY 14853, USA.
Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA.
Cell. 2014 Jul 17;158(2):250-262. doi: 10.1016/j.cell.2014.06.037.
Human microbiome research is an actively developing area of inquiry, with ramifications for our lifestyles, our interactions with microbes, and how we treat disease. Advances depend on carefully executed, controlled, and reproducible studies. Here, we provide a Primer for researchers from diverse disciplines interested in conducting microbiome research. We discuss factors to be considered in the design, execution, and data analysis of microbiome studies. These recommendations should help researchers to enter and contribute to this rapidly developing field.
人类微生物组研究是一个活跃发展的研究领域，对我们的生活方式、与微生物的相互作用以及我们治疗疾病的方式都有影响。研究进展取决于精心执行、控制和可重复的研究。在这里，我们为来自不同学科的对进行微生物组研究感兴趣的研究人员提供了一个入门。我们讨论了在微生物组研究的设计、执行和数据分析中需要考虑的因素。这些建议应该有助于研究人员进入并为这个快速发展的领域做出贡献。
