Marais Ben J, Schaaf H Simon
Marie Bashir Institute for Infectious Diseases and Biosecurity (MBI) and The Children's Hospital at Westmead, University of Sydney, Westmead, New South Wales 2145, Australia.
Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, 7505, South Africa.
Cold Spring Harb Perspect Med. 2014 Jul 18;4(9):a017855. doi: 10.1101/cshperspect.a017855.
Many clinicians regard tuberculosis as an adult pulmonary disease, but tuberculosis (TB) is a major cause of disease, both pulmonary and extrapulmonary, and death in young children from TB-endemic countries, especially in areas affected by poverty, social disruption, and human immunodeficiency virus (HIV) infection. This article reviews the disease burden and the natural history of disease in children with TB. It also provides guidance regarding the diagnosis, treatment, and prevention of TB in children.
许多临床医生认为结核病是一种成人肺部疾病,但在结核病流行国家,尤其是在受贫困、社会动荡和人类免疫缺陷病毒(HIV)感染影响的地区,结核病是幼儿发病(包括肺部和肺外疾病)和死亡的主要原因。本文综述了儿童结核病的疾病负担和自然病史。它还提供了关于儿童结核病诊断、治疗和预防的指导。