免疫系统的神经控制。
Neural control of the immune system.
作者信息
Sundman Eva, Olofsson Peder S
出版信息
Adv Physiol Educ. 2014 Jun;38(2):135-9. doi: 10.1152/advan.00094.2013.
Abstract
Neural reflexes support homeostasis by modulating the function of organ systems. Recent advances in neuroscience and immunology have revealed that neural reflexes also regulate the immune system. Activation of the vagus nerve modulates leukocyte cytokine production and alleviates experimental shock and autoimmune disease, and recent data have suggested that vagus nerve stimulation can improve symptoms in human rheumatoid arthritis. These discoveries have generated an increased interest in bioelectronic medicine, i.e., therapeutic delivery of electrical impulses that activate nerves to regulate immune system function. Here, we discuss the physiology and potential therapeutic implications of neural immune control.
摘要
神经反射通过调节器官系统的功能来维持体内平衡。神经科学和免疫学的最新进展表明，神经反射也调节免疫系统。迷走神经的激活可调节白细胞细胞因子的产生，并减轻实验性休克和自身免疫性疾病，最近的数据表明，迷走神经刺激可改善人类类风湿性关节炎的症状。这些发现引发了人们对生物电子医学的更多兴趣，即通过电脉冲治疗性传递来激活神经以调节免疫系统功能。在这里，我们讨论神经免疫控制的生理学及潜在治疗意义。
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