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实验性炎症中急性迷走神经刺激的一种有效方法。

An Effective Method for Acute Vagus Nerve Stimulation in Experimental Inflammation.

作者信息

Caravaca April S, Gallina Alessandro L, Tarnawski Laura, Tracey Kevin J, Pavlov Valentin A, Levine Yaakov A, Olofsson Peder S

机构信息

Laboratory of Immunobiology, Center for Bioelectronic Medicine, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.

Center for Biomedical Science and Bioelectronic Medicine, The Feinstein Institute for Medical Research, Manhasset, NY, United States.

出版信息

Front Neurosci. 2019 Aug 27;13:877. doi: 10.3389/fnins.2019.00877. eCollection 2019.

DOI:10.3389/fnins.2019.00877
PMID:31551672
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6736627/
Abstract

Neural reflexes regulate inflammation and electrical activation of the vagus nerve reduces inflammation in models of inflammatory disease. These discoveries have generated an increasing interest in targeted neurostimulation as treatment for chronic inflammatory diseases. Data from the first clinical trials that use vagus nerve stimulation (VNS) in treatment of rheumatoid arthritis and Crohn's disease suggest that there is a therapeutic potential of electrical VNS in diseases characterized by excessive inflammation. Accordingly, there is an interest to further explore the molecular mechanisms and therapeutic potential of electrical VNS in a range of experimental settings and available genetic mouse models of disease. Here, we describe a method for electrical VNS in experimental inflammation in mice.

摘要

神经反射调节炎症，并且在炎症性疾病模型中，迷走神经的电激活可减轻炎症。这些发现使得人们对靶向神经刺激作为慢性炎症性疾病的治疗方法越来越感兴趣。首批使用迷走神经刺激（VNS）治疗类风湿性关节炎和克罗恩病的临床试验数据表明，电刺激VNS在以炎症过度为特征的疾病中具有治疗潜力。因此，人们有兴趣在一系列实验环境和可用的疾病基因小鼠模型中进一步探索电刺激VNS的分子机制和治疗潜力。在此，我们描述一种在小鼠实验性炎症中进行电刺激VNS的方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a91/6736627/40bd9aee3139/fnins-13-00877-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a91/6736627/177ac1fb7a1a/fnins-13-00877-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a91/6736627/5ef810bc4660/fnins-13-00877-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a91/6736627/dc871cded168/fnins-13-00877-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a91/6736627/9b59a637aa00/fnins-13-00877-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a91/6736627/9cd9c5f729a1/fnins-13-00877-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a91/6736627/c9885e428aee/fnins-13-00877-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a91/6736627/40bd9aee3139/fnins-13-00877-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a91/6736627/177ac1fb7a1a/fnins-13-00877-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a91/6736627/d20ad1bbc8cf/fnins-13-00877-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a91/6736627/30af52b20921/fnins-13-00877-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a91/6736627/5ef810bc4660/fnins-13-00877-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a91/6736627/dc871cded168/fnins-13-00877-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a91/6736627/9b59a637aa00/fnins-13-00877-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a91/6736627/9cd9c5f729a1/fnins-13-00877-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a91/6736627/c9885e428aee/fnins-13-00877-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a91/6736627/40bd9aee3139/fnins-13-00877-g009.jpg

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