Chavan Sangeeta S, Pavlov Valentin A, Tracey Kevin J
Center for Biomedical Science, Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY 11030, USA; Center for Bioelectronic Medicine, Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY 11030, USA.
Immunity. 2017 Jun 20;46(6):927-942. doi: 10.1016/j.immuni.2017.06.008.
Active research at the frontiers of immunology and neuroscience has identified multiple points of interaction and communication between the immune system and the nervous system. Immune cell activation stimulates neuronal circuits that regulate innate and adaptive immunity. Molecular mechanistic insights into the inflammatory reflex and other neuro-immune interactions have greatly advanced our understanding of immunity and identified new therapeutic possibilities in inflammatory and autoimmune diseases. Recent successful clinical trials using bioelectronic devices that modulate the inflammatory reflex to significantly ameliorate rheumatoid arthritis and inflammatory bowel disease provide a path for using electrons as a therapeutic modality for targeting molecular mechanisms of immunity. Here, we review mechanisms of peripheral sensory neuronal function in response to immune challenges, the neural regulation of immunity and inflammation, and the therapeutic implications of those mechanistic insights.
免疫学和神经科学前沿的积极研究已经确定了免疫系统和神经系统之间的多个相互作用和通信点。免疫细胞激活会刺激调节先天性和适应性免疫的神经回路。对炎症反射和其他神经免疫相互作用的分子机制的深入了解极大地推进了我们对免疫的理解，并确定了炎症和自身免疫性疾病的新治疗可能性。最近使用生物电子设备调节炎症反射以显著改善类风湿性关节炎和炎症性肠病的成功临床试验为将电子作为靶向免疫分子机制的治疗方式提供了一条途径。在这里，我们综述了外周感觉神经元在应对免疫挑战时的功能机制、免疫和炎症的神经调节以及这些机制见解的治疗意义。
