N-三氟甲基硫代糖精：一种易于获得、储存稳定、广泛适用的三氟甲基硫代试剂。
N-trifluoromethylthiosaccharin: an easily accessible, shelf-stable, broadly applicable trifluoromethylthiolating reagent.
机构信息
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032 (China).
出版信息
Angew Chem Int Ed Engl. 2014 Aug 25;53(35):9316-20. doi: 10.1002/anie.201403983. Epub 2014 Jul 7.
A new, electrophilic trifluoromethylthiolating reagent, N-trifluoromethylthiosaccharin, was developed and can be synthesized in two steps from saccharin within 30 minutes. N-trifluoromethylthiosaccharin is a powerful trifluoromethylthiolating reagent and allows the trifluoromethylthiolation of a variety of nucleophiles such as alcohols, amines, thiols, electron-rich arenes, aldehydes, ketones, acyclic β-ketoesters, and alkynes under mild reaction conditions.
一种新的亲电子三氟甲基化硫试剂 N-三氟甲基硫代糖精被开发出来，可在 30 分钟内从糖精经两步合成得到。N-三氟甲基硫代糖精是一种强效的三氟甲基化硫试剂，可在温和的反应条件下实现各种亲核试剂如醇、胺、硫醇、富电子芳环、醛、酮、非环β-酮酯和炔烃的三氟甲基化。
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