Etzold Sabrina, Bode Lars
Division of Neonatology and Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, School of Medicine, University of California San Diego, 9500 Gilman Drive, San Diego, CA 92093-0715, USA.
Division of Neonatology and Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, School of Medicine, University of California San Diego, 9500 Gilman Drive, San Diego, CA 92093-0715, USA.
Curr Opin Virol. 2014 Aug;7:101-7. doi: 10.1016/j.coviro.2014.06.005. Epub 2014 Jul 19.
Glycan interactions play a crucial role in the infection of rotavirus (RV), norovirus (NV) and human immunodeficiency virus (HIV) as they facilitate viral attachment to the host receptor cell. A number of cell surface glycan epitopes involved in this process have been identified, including human blood group antigens (HBGAs). These antigens are also found on human milk oligosaccharides (HMO), an abundant and structurally diverse component in human milk. Breast-fed infants seem to have a reduced risk of acquiring RV, NV and HIV infection, suggesting a potential effector function of milk oligosaccharides in viral pathogenesis. However, the underlying mechanisms of HMO in viral protection and the identification of individual, structurally distinct effective HMO, needs further elucidation.
聚糖相互作用在轮状病毒（RV）、诺如病毒（NV）和人类免疫缺陷病毒（HIV）感染中起着关键作用，因为它们有助于病毒附着于宿主受体细胞。已确定了参与这一过程的一些细胞表面聚糖表位，包括人类血型抗原（HBGAs）。这些抗原也存在于人乳寡糖（HMO）中，HMO是人乳中丰富且结构多样的成分。母乳喂养的婴儿感染RV、NV和HIV的风险似乎较低，这表明乳寡糖在病毒发病机制中具有潜在的效应功能。然而，HMO在病毒保护中的潜在机制以及鉴定结构上不同的单个有效HMO，仍需要进一步阐明。
