用于乳腺癌检测的单频太赫兹成像系统的开发与测试。
Development and testing of a single frequency terahertz imaging system for breast cancer detection.
作者信息
St Peter Benjamin, Yngvesson Sigfrid, Siqueira Paul, Kelly Patrick, Khan Ashraf, Glick Stephen, Karellas Andrew
出版信息
IEEE J Biomed Health Inform. 2013 Jul;17(4):785-97. doi: 10.1109/JBHI.2013.2267351.
The ability to discern malignant from benign tissue in excised human breast specimens in Breast Conservation Surgery (BCS) was evaluated using single frequency terahertz radiation. Terahertz (THz) images of the specimens in reflection mode were obtained by employing a gas laser source and mechanical scanning. The images were correlated with optical histological micrographs of the same specimens, and a mean discrimination of 73% was found for five out of six samples using Receiver Operating Characteristic (ROC) analysis. The system design and characterization is discussed in detail. The initial results are encouraging but further development of the technology and clinical evaluation is needed to evaluate its feasibility in the clinical environment.
利用单频太赫兹辐射评估了保乳手术（BCS）中从切除的人类乳腺标本中辨别恶性组织与良性组织的能力。通过使用气体激光源和机械扫描，以反射模式获取了标本的太赫兹（THz）图像。将这些图像与相同标本的光学组织学显微照片进行关联，使用接受者操作特征（ROC）分析发现，六个样本中有五个样本的平均辨别率为73%。详细讨论了系统设计和特性。初步结果令人鼓舞，但需要进一步开展技术研发和临床评估，以评估其在临床环境中的可行性。
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