有乳腺癌或卵巢癌家族史女性的癌症风险意识与担忧
Cancer Risk Awareness and Concern among Women with a Family History of Breast or Ovarian Cancer.
作者信息
Andersen M Robyn, Thorpe Jason, Buist Diana S M, Beatty J David, Watabayashi Kate, Hanson Nancy, Resta Robert, Chubak Jessica, Urban Nicole
机构信息
a Fred Hutchinson Cancer Research Center and University of Washington.
b Fred Hutchinson Cancer Research Center.
出版信息
Behav Med. 2016;42(1):18-28. doi: 10.1080/08964289.2014.947234. Epub 2014 Nov 3.
Women with a documented deleterious mutation in BRCA1 or BRCA2 are at substantially elevated risk for ovarian cancer. To understand what percentage of women with high-risk family histories know their risk is elevated we surveyed 1,885 women with a high- or moderate-risk family history and no personal history of breast or ovarian cancer, and asked about their perceived risk of breast and ovarian cancer. Among high-risk women, fewer than 20% reported use of genetic counseling, and knowledge of elevated risk of ovarian cancer was low. Prior genetic counseling was associated with greater perceived risk for ovarian cancer. Results suggest that most high-risk women (>75%) do not know their risk for ovarian cancer. Identification of potentially high-risk women for referral to genetic counseling may improve informed ovarian cancer risk management.
携带BRCA1或BRCA2基因有害突变记录的女性患卵巢癌的风险大幅升高。为了解有高危家族史的女性中知晓自身风险升高的比例，我们对1885名有高风险或中度风险家族史且无乳腺癌或卵巢癌个人史的女性进行了调查，并询问她们对乳腺癌和卵巢癌的感知风险。在高危女性中，报告接受过遗传咨询的不到20%，对卵巢癌风险升高的知晓率较低。先前的遗传咨询与更高的卵巢癌感知风险相关。结果表明，大多数高危女性（>75%）不知道自己患卵巢癌的风险。识别潜在的高危女性以便转诊进行遗传咨询，可能会改善卵巢癌风险的知情管理。
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