Kouhnavard Marjan, Nasli Esfahani Ensieh, Montazeri Mohammad, Hashemian Seyed Jafar, Mehrazma Mitra, Larijani Bagher, Nezami Asl Amir, Khoshvaghti Amir, Falsafi Ammar, Lalehfar Komeil, Malekpour Keyvan, Vosugh Mehran
Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences , Tehran, IR Iran ; Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran , IR Iran.
Young Researchers Club, Babol Branch, Babol, IR Iran.
Iran Red Crescent Med J. 2014 Jun;16(6):e18026. doi: 10.5812/ircmj.18026. Epub 2014 Jun 5.
Revealing data on the role of vitamin D and calcium supplementation in bone health has led some to suggest that vitamin D and calcium treatment could also play a role in protecting bone against microgravity-induced mineral loss.
The aim of the present study was to investigate the effects of vitamin D and calcium administration on microscopic and densitometric changes of rat femur in a Microgravity Simulator Model.
After designing a Microgravity Simulator Model, 14 rats were placed in the cages as follows: seven rats as osteoporosis group and seven rats received oral supplement of calcium/vitamin D as the treatment group. Animals were sacrificed after eight weeks and then both femurs were removed. Bone mineral density was measured for one femur from each animal, and morphologic studies were evaluated for the contralateral femur.
Bone mineral density of the whole femur in the treatment group was significantly higher than the osteoporosis group (0.168 ± 0.005 vs. 0.153 ± 0.006, P = 0.003). Also, bone mineral content of the whole femur was significantly higher in treatment group (0.415 ± 0.016 vs. 0.372 ± 0.019, P = 0.003). However, resorption eroded surface percentage was higher in the osteoporosis group (18.86 ± 3.71% vs. 9.71 ± 1.61%, P = 0.002).
According to the results of this study, vitamin D and calcium administration might have protective effects against microgravity-induced mineral loss in a Rat Microgravity Simulator Model.
有关维生素D和钙补充剂在骨骼健康中作用的数据表明,维生素D和钙治疗可能也有助于保护骨骼免受微重力引起的矿物质流失。
本研究旨在调查在微重力模拟器模型中给予维生素D和钙对大鼠股骨微观和密度测量变化的影响。
设计微重力模拟器模型后,将14只大鼠置于笼中,分组如下:7只大鼠作为骨质疏松组,7只大鼠接受钙/维生素D口服补充剂作为治疗组。8周后处死动物,然后取出双侧股骨。测量每只动物一侧股骨的骨矿物质密度,并对另一侧股骨进行形态学研究评估。
治疗组全股骨的骨矿物质密度显著高于骨质疏松组(0.168±0.005对0.153±0.006,P = 0.003)。此外,治疗组全股骨的骨矿物质含量也显著更高(0.415±0.016对0.372±0.019,P = 0.003)。然而,骨质疏松组的吸收侵蚀表面百分比更高(18.86±3.71%对9.71±1.61%,P = 0.002)。
根据本研究结果,在大鼠微重力模拟器模型中,给予维生素D和钙可能对微重力引起的矿物质流失具有保护作用。