Wang Ying, Tashiro Yukihiro, Sonomoto Kenji
Laboratory of Microbial Technology, Division of Applied Molecular Microbiology and Biomass Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan.
Institute of Advanced Study, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan; Laboratory of Soil Microbiology, Division of Applied Molecular Microbiology and Biomass Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan.
J Biosci Bioeng. 2015 Jan;119(1):10-8. doi: 10.1016/j.jbiosc.2014.06.003. Epub 2014 Jul 27.
The development and implementation of renewable materials for the production of versatile chemical resources have gained considerable attention recently, as this offers an alternative to the environmental problems caused by the petroleum industry and the limited supply of fossil resources. Therefore, the concept of utilizing biomass or wastes from agricultural and industrial residues to produce useful chemical products has been widely accepted. Lactic acid plays an important role due to its versatile application in the food, medical, and cosmetics industries and as a potential raw material for the manufacture of biodegradable plastics. Currently, the fermentative production of optically pure lactic acid has increased because of the prospects of environmental friendliness and cost-effectiveness. In order to produce lactic acid with high yield and optical purity, many studies focus on wild microorganisms and metabolically engineered strains. This article reviews the most recent advances in the biotechnological production of lactic acid mainly by lactic acid bacteria, and discusses the feasibility and potential of various processes.
近年来，用于生产多种化学资源的可再生材料的开发与应用受到了广泛关注，因为这为解决石油工业造成的环境问题以及化石资源供应有限的问题提供了一种替代方案。因此，利用生物质或农业及工业残渣废弃物来生产有用化学产品的概念已被广泛接受。乳酸因其在食品、医药和化妆品行业的广泛应用以及作为制造可生物降解塑料的潜在原料而发挥着重要作用。目前，由于具有环境友好和成本效益的前景，光学纯乳酸的发酵生产有所增加。为了高产且高光学纯度地生产乳酸，许多研究集中在野生微生物和代谢工程菌株上。本文综述了主要由乳酸菌进行生物技术生产乳酸的最新进展，并讨论了各种工艺的可行性和潜力。
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