通过果蝇的体细胞和生殖系镶嵌试验以及性连锁隐性致死试验检测代森锌的遗传毒性。

Genotoxicity of zineb detected through the somatic and germ-line mosaic assays and the sex-linked recessive-lethal test in Drosophila melanogaster.

作者信息

Tripathy N K, Dey L, Majhi B, Das C C

机构信息

Department of Zoology, Berhampur University, India.

出版信息

Mutat Res. 1988 Sep;206(1):25-31. doi: 10.1016/0165-1218(88)90137-1.

DOI:10.1016/0165-1218(88)90137-1

PMID:3137464

Abstract

The genotoxicity of zineb, a carbamate fungicide, has been tested through eye, wing and female germ line mosaic assays and the sex-linked recessive-lethal test in Drosophila melanogaster. Larvae of different instars, heterozygous for appropriate recessive genetic markers, were exposed to the fungicide in food for different durations of time. The adult eyes and wings were screened for induction of mosaic spots and the eggs laid by the females were checked for induction of female germ-line mosaicism. It is concluded that zineb is genotoxic to both somatic and germ-line cells of Drosophila.

摘要

代森锌（一种氨基甲酸盐类杀菌剂）的遗传毒性已通过果蝇的眼、翅和雌性生殖系嵌合体试验以及性连锁隐性致死试验进行了检测。不同龄期、携带适当隐性遗传标记杂合子的幼虫在食物中接触该杀菌剂不同时长。对成虫的眼和翅进行筛查，以检测嵌合斑的诱导情况，并检查雌性所产卵，以检测雌性生殖系嵌合现象的诱导情况。得出的结论是，代森锌对果蝇的体细胞和生殖系细胞均具有遗传毒性。