利用黄连对氧化锌纳米颗粒进行表征、抗菌、抗氧化及细胞毒性活性研究。
Characterization, antibacterial, antioxidant, and cytotoxic activities of ZnO nanoparticles using Coptidis Rhizoma.
作者信息
Nagajyothi P C, Sreekanth T V M, Tettey Clement O, Jun Yang In, Mook Shin Heung
机构信息
Department of Physiology, College of Oriental Medicine, Dongguk University, Gyeongju, South Korea.
Department of Life Chemistry, Catholic University of Daegu, Gyeongsan 712-702, South Korea.
出版信息
Bioorg Med Chem Lett. 2014 Sep 1;24(17):4298-303. doi: 10.1016/j.bmcl.2014.07.023. Epub 2014 Jul 15.
Here, we report a simple, eco-friendly and inexpensive approach for the synthesis of zinc oxide nanoparticles (ZnO NPs) using Coptidis Rhizoma. The ZnO NPs were characterized by UV-visible absorption spectroscopy, FTIR, SEM-EDX, TGA, TEM, SAED and XRD. TEM images confirmed the presence of spherical and rod shaped ZnO NPs in the range of 2.90-25.20 nm. Green synthesized ZnO NPS exhibited moderate antibacterial activity against Gram-positive and Gram-negative bacteria and excellent DPPH free radical scavenging activity. Synthesized ZnO NPs had no toxic effects on the RAW 264.7 cell line.
在此，我们报道了一种使用黄连合成氧化锌纳米颗粒（ZnO NPs）的简单、环保且廉价的方法。通过紫外可见吸收光谱、傅里叶变换红外光谱、扫描电子显微镜-能谱仪、热重分析、透射电子显微镜、选区电子衍射和X射线衍射对ZnO NPs进行了表征。透射电子显微镜图像证实存在尺寸在2.90 - 25.20 nm范围内的球形和棒状ZnO NPs。绿色合成的ZnO NPs对革兰氏阳性菌和革兰氏阴性菌表现出中等抗菌活性以及出色的二苯基苦味酰基自由基清除活性。合成的ZnO NPs对RAW 264.7细胞系没有毒性作用。
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