Karmous Inès, Taheur Fadia Ben, Zuverza-Mena Nubia, Jebahi Samira, Vaidya Shital, Tlahig Samir, Mhadhbi Mohsen, Gorai Mustapha, Raouafi Amel, Debara Mohamed, Bouhamda Talel, Dimkpa Christian O
Institute of Applied Biology of Medenine, University of Gabes, Medenine 4100, Tunisia.
Plant Toxicology and Molecular Biology of Microorganisms, Faculty of Sciences of Bizerte, Jarzouna 7021, Tunisia.
Plants (Basel). 2022 Nov 14;11(22):3079. doi: 10.3390/plants11223079.
Carob ( L.) is a tree crop cultivated extensively in the eastern Mediterranean regions but that has become naturalized in other regions as well. The present study focused on the green synthesis of zinc oxide nanoparticles (ZnONPs) from Carob and their evaluation for antimicrobial activity in bacteria and fungi. The synthesized ZnONPs showed strong antibacterial activity against ATCC 25 923 (92%). The NPs inhibited the growth of pathogenic yeast strains, including ATCC90028, ATCC6258, and ATCC14116, by 90%, 91%, and 82%, respectively, compared to the control. Fungal inhibition zones with the ZnONPs were 88.67% and 90%, respectively, larger for 15UA005 and ATCC204305, compared to control fungal growth. This study provides novel information relevant for plant-based development of new and potentially antimicrobial ZnONPs based on extracts. In particular, the development and application of phytogenic nanoparticles enhances the biocompatibility of nano-scale materials, thereby allowing to tune effects to prevent adverse outcomes in non-target biological systems.
角豆树（学名：Ceratonia siliqua L.）是一种在东地中海地区广泛种植的树木作物，但在其他地区也已归化。本研究聚焦于利用角豆树进行氧化锌纳米颗粒（ZnONPs）的绿色合成及其对细菌和真菌抗菌活性的评估。合成的ZnONPs对ATCC 25923表现出较强的抗菌活性（92%）。与对照相比，这些纳米颗粒分别抑制了包括ATCC90028、ATCC6258和ATCC14116在内的致病酵母菌株生长90%、91%和82%。与对照真菌生长相比，对于15UA005和ATCC204305，ZnONPs的真菌抑制区分别大88.67%和90%。本研究提供了与基于植物提取物开发新型且具有潜在抗菌性的ZnONPs相关的新信息。特别是，植物源纳米颗粒的开发和应用增强了纳米级材料的生物相容性，从而能够调节效果以防止非靶标生物系统中出现不良后果。
