Wang Yan, Zeng Xian-bo, Yao Feng-juan, Wu Fang, Su Chen, Fan Zhen-guo, Zhu Zhu, Tao Jun, Huang Yi-jun
Physical examination center, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Education School of Sun Yat-Sen University, Guangzhou, China.
PLoS One. 2014 Aug 7;9(8):e103814. doi: 10.1371/journal.pone.0103814. eCollection 2014.
Endurance capacity, assessed by 1000-meter (1000 m) run of male university students, is an indicator of cardiovascular fitness in Chinese students physical fitness surveillance. Although cardiovascular fitness is related to endothelial function closely in patients with cardiovascular diseases, it remains unclear whether endurance capacity correlates with endothelial function, especially with circulating endothelial microparticles (EMPs), a new sensitive marker of endothelial dysfunction in young students. The present study aimed to investigate the relationship between endurance capacity and endothelial function in male university students.
Forty-seven healthy male university students (mean age, 20.1 ± 0.6 years; mean height, 172.4 ± 6.3 cm; and mean weight, 60.0 ± 8.2 kg) were recruited in this study. The measurement procedure of 1000 m run time was followed to Chinese national students Constitutional Health Criterion. Endothelium function was assessed by flow-mediated vasodilation (FMD) in the brachial artery measured by ultrasonic imaging, and the level of circulating EMPs was measured by flow cytometry. Cardiovascular fitness indicator--maximal oxygen uptake (VO2max)--was also measured on a cycle ergometer using a portable gas analyzer.
1000 m run time was correlated with VO2max (r = -0.399, p<0.05). However, there were no correlations between VO2max and FMD or levels of circulating CD31+/CD42- microparticles. Similarly, no correlations were found between 1000 m run time and FMD, and levels of circulating CD31+/CD42- microparticles in these male university students (p>0.05).
The correlations between endurance capacity or cardiovascular fitness and endothelial function were not found in healthy Chinese male university students. These results suggest that endurance capacity may not reflect endothelial function in healthy young adults with well preserved FMD and low level of circulating CD31+/CD42-EMPs.
在中国学生体质监测中，通过对男大学生进行1000米跑测试来评估耐力，这是心血管健康的一项指标。虽然在心血管疾病患者中，心血管健康与内皮功能密切相关，但耐力是否与内皮功能相关，尤其是与循环内皮微粒（EMPs）这一青年学生内皮功能障碍的新敏感标志物之间的关系仍不明确。本研究旨在探讨男大学生耐力与内皮功能之间的关系。
本研究招募了47名健康男大学生（平均年龄20.1±0.6岁；平均身高172.4±6.3厘米；平均体重60.0±8.2千克）。1000米跑时间的测量程序遵循中国国家学生体质健康标准。采用超声成像测量肱动脉血流介导的血管舒张（FMD）来评估内皮功能，通过流式细胞术测量循环EMPs水平。还使用便携式气体分析仪在功率自行车上测量心血管健康指标——最大摄氧量（VO2max）。
1000米跑时间与VO2max相关（r = -0.399，p<0.05）。然而，VO2max与FMD或循环CD31+/CD42-微粒水平之间无相关性。同样，在这些男大学生中，1000米跑时间与FMD以及循环CD31+/CD42-微粒水平之间也未发现相关性（p>0.05）。
在健康的中国男大学生中未发现耐力或心血管健康与内皮功能之间的相关性。这些结果表明，在FMD良好且循环CD31+/CD42-EMPs水平较低的健康年轻成年人中耐力可能无法反映内皮功能。
