日常积极事件与炎症：来自全国日常经历研究的发现
Daily positive events and inflammation: findings from the National Study of Daily Experiences.
作者信息
Sin Nancy L, Graham-Engeland Jennifer E, Almeida David M
机构信息
Center for Healthy Aging, The Pennsylvania State University, University Park, PA, USA.
Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA, USA.
出版信息
Brain Behav Immun. 2015 Jan;43:130-8. doi: 10.1016/j.bbi.2014.07.015. Epub 2014 Aug 4.
BACKGROUND
Inflammation is implicated in the development of chronic diseases and increases the risk of mortality. People who experience more daily stressors than others have higher levels of inflammation, but it is unknown whether daily positive events are linked to inflammation.
OBJECTIVE
To examine the association of daily positive events with 3 inflammatory markers, interleukin-6 (IL-6), C-reactive protein (CRP), and fibrinogen.
METHOD
A cross-sectional sample of 969 adults aged 35-86 from the Midlife in the United States Study completed telephone interviews for 8 consecutive evenings. Participants reported positive experiences that occurred over the past 24h. Blood samples were obtained at a separate clinic visit and later assayed for inflammatory markers. Regression analyses evaluated the frequency of daily positive events (defined as the percent of study days with at least 1 positive event) as a predictor of each inflammatory marker. Covariates included information on demographics, physical health, depressive symptoms, dispositional and behavioral factors, and daily positive and negative affect.
RESULTS
On average, participants experienced positive events on 73% of days (SD=27%). The frequency of daily positive events was associated with lower IL-6 (p<0.001) and CRP (p=0.02) in the overall sample, and lower fibrinogen among women (p=0.01). The association remained for IL-6 in the fully adjusted model, but was no longer significant for CRP and fibrinogen after controlling for household income and race. Effects were more pronounced for participants in the lowest quartile of positive event frequency than for those in the top 3 quartiles, suggesting that lack of positivity in daily life may be particularly consequential for inflammation. Furthermore, interpersonal positive events were more predictive of lower IL-6 overall and lower fibrinogen in women than non-interpersonal positive events.
CONCLUSION
Daily positive events may serve a protective role against inflammation.
背景
炎症与慢性疾病的发展有关，并增加死亡风险。每天经历更多压力源的人炎症水平更高，但尚不清楚日常积极事件是否与炎症有关。
目的
研究日常积极事件与三种炎症标志物白细胞介素-6（IL-6）、C反应蛋白（CRP）和纤维蛋白原之间的关联。
方法
从美国中年研究中选取969名年龄在35至86岁之间的成年人作为横断面样本，连续8个晚上完成电话访谈。参与者报告过去24小时内发生的积极经历。在另一次门诊就诊时采集血样，随后检测炎症标志物。回归分析评估日常积极事件的频率（定义为至少有1次积极事件的研究天数百分比）作为每种炎症标志物的预测指标。协变量包括人口统计学、身体健康、抑郁症状、性格和行为因素以及日常积极和消极情绪方面的信息。
结果
平均而言，参与者在73%的日子里经历了积极事件（标准差=27%）。在总体样本中，日常积极事件的频率与较低的IL-6（p<0.001）和CRP（p=0.02）相关，在女性中与较低的纤维蛋白原相关（p=0.01）。在完全调整模型中，IL-6的关联仍然存在，但在控制家庭收入和种族后，CRP和纤维蛋白原的关联不再显著。对于积极事件频率处于最低四分位数的参与者，影响比处于最高三分位数的参与者更为明显，这表明日常生活中缺乏积极性可能对炎症尤为重要。此外，人际积极事件比非人际积极事件更能预测总体较低的IL-6和女性较低的纤维蛋白原。
结论
日常积极事件可能对炎症起到保护作用。
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