Burke Benjamin P, Clemente Gonçalo S, Archibald Stephen J
Department of Chemistry, University of Hull, Hull, HU6 7RX, UK; Positron Emission Tomography Research Centre, University of Hull, Hull, HU6 7RX, UK.
Contrast Media Mol Imaging. 2015 Mar-Apr;10(2):96-110. doi: 10.1002/cmmi.1615. Epub 2014 Aug 8.
Standard [(18) F]fluorination methods to form carbon-fluorine bonds can have some limitations such as low yield and the requirement for harsh reaction conditions. Inorganic approaches include the formation of boron-[(18) F]fluorine bonds and have the potential to give high specific activities at room temperature forming a bond that is stable in vivo. There is considerable potential in future applications, particularly in relation to multimodal imaging and the provision of rapid efficient labelling protocols.
形成碳-氟键的标准[(18)F]氟化方法可能存在一些局限性，例如产率低以及需要苛刻的反应条件。无机方法包括形成硼-[(18)F]氟键，并且有可能在室温下获得高比活度，形成在体内稳定的键。在未来的应用中具有相当大的潜力，特别是在多模态成像和提供快速高效的标记方案方面。
