Jackson Mary
Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Colorado 80523-1682.
Cold Spring Harb Perspect Med. 2014 Aug 7;4(10):a021105. doi: 10.1101/cshperspect.a021105.
Mycobacterium tuberculosis (Mtb) lipids are indelibly imprinted in just about every key aspect of tuberculosis (TB) basic and translational research. Although the interest in these compounds originally stemmed from their abundance, structural diversity, and antigenicity, continued research in this field has been driven by their important contribution to TB pathogenesis and their interest from the perspective of drug, vaccine, diagnostic, and biomarker development. This article summarizes what is known of the roles of lipids in the physiology and pathogenicity of Mtb and the exciting developments that have occurred in recent years in identifying new lead compounds targeting their biogenesis.
结核分枝杆菌(Mtb)的脂质在结核病(TB)基础研究和转化研究的几乎每个关键方面都留下了不可磨灭的印记。尽管最初对这些化合物的兴趣源于它们的丰富性、结构多样性和抗原性,但该领域的持续研究是由它们对结核病发病机制的重要贡献以及从药物、疫苗、诊断和生物标志物开发角度来看的吸引力所推动的。本文总结了目前已知的脂质在结核分枝杆菌生理和致病性中的作用,以及近年来在鉴定靶向其生物合成的新先导化合物方面所取得的令人兴奋的进展。