Kim Chung-Hoon, Lee You-Jeong, Lee Kyung-Hee, Kwon Su-Kyung, Kim Sung-Hoon, Chae Hee-Dong, Kang Byung-Moon
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
Obstet Gynecol Sci. 2014 Jul;57(4):291-6. doi: 10.5468/ogs.2014.57.4.291. Epub 2014 Jul 15.
To evaluate the effect of progesterone supplementation during the luteal phase on pregnancy outcome in natural frozen-thawed embyo transfer (FTET) cycles.
In this retrospective cohort study, 228 consecutive patients who underwent FTET cycles between January 2009 and September 2012 were included. One hundred forty-five patients received luteal progesterone support (P group) but 83 patients did not receive any progesterone supplementation during luteal phase (control group).
There were no differences in patients' characteristics between the two groups. The two groups were similar with respect to the characteristics of previous fresh in vitro fertilization cycle in which embryos were cryopreserved including the numbers of oocytes retrieved, mature oocytes, fertilized oocytes, grade 1 or 2 embryos and frozen embryos. Also, significant differences were not observed between the P and control groups in clinical pregnancy rate, embryo implantation rate and multiple pregnancy rate. However, miscarriage rate was significantly lower in the P group and live birth rate was significantly higher in the P group than in the control group (P<0.05, P<0.05).
Our results suggest that luteal phase progesterone supplementation decreases miscarriage rate and improves live birth rate in natural FTET cycles.
评估黄体期补充孕激素对自然冻融胚胎移植（FTET）周期妊娠结局的影响。
在这项回顾性队列研究中，纳入了2009年1月至2012年9月期间连续进行FTET周期的228例患者。145例患者接受黄体期孕激素支持（P组），但83例患者在黄体期未接受任何孕激素补充（对照组）。
两组患者的特征无差异。两组在之前冷冻胚胎的新鲜体外受精周期特征方面相似，包括获取的卵母细胞数量、成熟卵母细胞、受精卵母细胞、1级或2级胚胎以及冷冻胚胎数量。此外，P组和对照组在临床妊娠率、胚胎着床率和多胎妊娠率方面未观察到显著差异。然而，P组的流产率显著低于对照组，P组的活产率显著高于对照组（P<0.05，P<0.05）。
我们的结果表明，黄体期补充孕激素可降低自然FTET周期的流产率并提高活产率。
