磁铁矿纳米颗粒的过氧化物酶样活性引发的膜脂质过氧化作用。
Membrane lipid peroxidation by the peroxidase-like activity of magnetite nanoparticles.
作者信息
Wang Lijun, Min Yue, Xu Doudou, Yu Fengjiao, Zhou Wuzong, Cuschieri Alfred
机构信息
Institute for Medical Science and Technology, College of Medicine, Dentistry and Nursing, University of Dundee, Dundee DD2 1FD, UK.
出版信息
Chem Commun (Camb). 2014 Oct 4;50(76):11147-50. doi: 10.1039/c4cc03082f.
PMID:25109366
Abstract
We report that Fe3O4 nanoparticles are able to catalyse lipid peroxidation in liposomes at acidic but not neutral pH. The oxidation is dependent on either pre-existing lipid peroxides or hydrogen peroxide as a substrate. This is the first evidence for metal oxide nanoparticles as peroxidase mimetics oxidising biomolecules in a relevant environment.
摘要
我们报告称，Fe3O4纳米颗粒能够在酸性而非中性pH条件下催化脂质体中的脂质过氧化反应。这种氧化反应依赖于预先存在的脂质过氧化物或过氧化氢作为底物。这是金属氧化物纳米颗粒作为过氧化物酶模拟物在相关环境中氧化生物分子的首个证据。
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