Corazza G R, Ginaldi L, Falasca A, Strocchi A, Rossi C A, Quaglino D, Gasbarrini G
Department of I Medical Pathology, University of Bologna, Italy.
J Clin Pathol. 1989 Nov;42(11):1136-9. doi: 10.1136/jcp.42.11.1136.
Diamine oxidase plasma concentrations after treatment with heparin were measured and compared with the surface to volume ratio of jejunal biopsy samples assessed by a morphometric technique in patients with untreated and treated coeliac disease and in biopsied controls. As expected, enzyme activity was significantly lower in patients with untreated coeliac disease than in patients on a gluten-free diet and in biopsied controls. No difference was found between treated patients and biopsied controls. There was a significant overall correlation between plasma enzyme activity and surface to volume ratio of jejunal mucosa, although two untreated patients without an overt malabsorption syndrome but with a very low surface to volume ratio had normal enzyme activity. This study shows that in coeliac disease plasma diamine oxidase activity after treatment with heparin does not always mirror the extent of the jejunal lesions, particularly in those patients with minimal or unrelated symptoms who would benefit most from a valid screening test to identify their condition.
测量了肝素治疗后血浆中二胺氧化酶的浓度，并将其与通过形态计量学技术评估的未经治疗和已治疗的乳糜泻患者以及活检对照的空肠活检样本的表面积与体积比进行了比较。正如预期的那样，未经治疗的乳糜泻患者的酶活性显著低于无麸质饮食的患者和活检对照。在已治疗的患者和活检对照之间未发现差异。血浆酶活性与空肠黏膜的表面积与体积比之间存在显著的总体相关性，尽管有两名未经治疗的患者没有明显的吸收不良综合征，但表面积与体积比非常低，其酶活性却正常。这项研究表明，在乳糜泻中，肝素治疗后血浆二胺氧化酶活性并不总是反映空肠病变的程度，特别是在那些症状轻微或无关的患者中，而这些患者最能从有效的筛查测试中受益以确定他们的病情。
