乳糜泻患者的空肠溶菌酶活性与潘氏细胞
Jejunal lysozyme activity and the Paneth cell in coeliac disease.
作者信息
Ward M, Ferguson A, Eastwood M A
出版信息
Gut. 1979 Jan;20(1):55-8. doi: 10.1136/gut.20.1.55.
Abstract
The jejunal mucosa of patients with coeliac disease contains significantly fewer Paneth cells (PCC) per crypt (p less than 0.001) and tissue lysozyme activity (JLA) P less than 0.001) when compared with a group of subjects with normal jejunal mucosa. Neither PCC nor JLA return to normal with complete clinical recovery and otherwise complete histological recovery on a gluten free diet. There is a significant linear correlation between JLA and PCC suggesting that the Paneth cell is the principal source of jejunal lysozyme.
摘要
与一组空肠黏膜正常的受试者相比，乳糜泻患者的空肠黏膜每个隐窝含有的潘氏细胞（PCC）显著减少（P<0.001），组织溶菌酶活性（JLA）也显著降低（P<0.001）。在无麸质饮食情况下，尽管临床完全恢复且组织学上也完全恢复，但PCC和JLA均未恢复正常。JLA与PCC之间存在显著的线性相关性，这表明潘氏细胞是空肠溶菌酶的主要来源。
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