Centre for Education and Research on Ageing, Concord Hospital, University of Sydney, Sydney, NSW 2139, Australia.
J Gerontol A Biol Sci Med Sci. 2013 Sep;68(9):1112-21. doi: 10.1093/gerona/glt059. Epub 2013 May 8.
Poor vitamin D status and frailty are common in older people and associated with adverse health outcomes. The aim of this study was to examine the associations between serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels and frailty and components of frailty in older Australian men.
Cross-sectional analysis of the Concord Health and Ageing in Men Project, a large epidemiological study conducted in Sydney, Australia, between January 2005 and May 2007. Participants included 1,659 community-dwelling men. Main outcome measurements were frailty (assessed using the Cardiovascular Health Study), frailty criteria comprising five core components: weight loss; reduced muscular strength/weakness; slow walking speed; exhaustion; and low activity level, and the separate components of frailty. Covariates included serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels measured by radioimmunoassay, age, country of birth, season of blood collection, sun exposure, body mass index, vitamin D supplement use, income, measures of health, parathyroid hormone, estimated glomerular function.
Frailty was present in 9.2% of the sample. Low serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels were independently associated with frailty and with four of the five components of frailty (except weight loss).
1,25-dihydroxyvitamin D and 25-hydroxyvitamin D levels were independently associated with frailty in older men. This suggests that there might be a number of different biological mechanisms for how low vitamin D status might contribute to the frailty syndrome. In addition, the possibility that improving vitamin D status may specifically influence the incidence and progression of frailty needs to be explored.
维生素 D 状态不佳和虚弱在老年人中很常见，并且与不良健康结果相关。本研究旨在研究血清 25-羟维生素 D 和 1,25-二羟维生素 D 水平与虚弱以及澳大利亚老年男性虚弱各组成部分之间的关联。
对澳大利亚悉尼进行的一项大型流行病学研究 Concord 健康与老龄化男性项目（2005 年 1 月至 2007 年 5 月）的横断面分析。参与者包括 1659 名居住在社区的男性。主要观察指标为虚弱（采用心血管健康研究评估），虚弱标准包括五个核心组成部分：体重减轻；肌肉力量/虚弱减少；步行速度慢；疲劳；活动水平低，以及虚弱的单独组成部分。协变量包括通过放射免疫测定法测量的血清 25-羟维生素 D 和 1,25-二羟维生素 D 水平、年龄、出生国家、采血季节、阳光照射、体重指数、维生素 D 补充剂使用、收入、健康状况、甲状旁腺激素、估计肾小球滤过率。
9.2%的样本存在虚弱。低血清 25-羟维生素 D 和 1,25-二羟维生素 D 水平与虚弱以及虚弱的五个组成部分中的四个（除体重减轻外）独立相关。
1,25-二羟维生素 D 和 25-羟维生素 D 水平与老年男性的虚弱独立相关。这表明，维生素 D 状态低下可能通过多种不同的生物学机制导致虚弱综合征。此外，需要探索改善维生素 D 状态是否可能特别影响虚弱的发生和进展。
