Unal Aydin, Kocyigit Ismail, Sipahioglu Murat Hahri, Tokgoz Bulent, Oymak Oktay
Department of Nephrology, Erciyes University Medical School, Kayseri, Turkey.
Ann Transplant. 2014 Aug 12;19:397-402. doi: 10.12659/AOT.890779.
The aim of this study was to determine whether there is a relationship between daily urinary sodium excretion and metabolic syndrome in kidney transplantation patients.
This cross-sectional study included 76 adult renal transplantation recipients. To calculate urinary sodium excretion, 24-h urine samples were collected. Metabolic syndrome was diagnosed according to Adult Treatment Panel III (ATP III) criteria updated in a statement from the American Heart Association (AHA)/National Heart, Lung, and Blood Institute (NHLBI) in 2005.
Mean age of the 76 patients was 38 ± 10 years; 21 of the 76 patients were female. Metabolic syndrome was found in 52 (68.4%) of the 76 renal transplantation patients. Mean daily urinary sodium excretion was 190 ± 102 mmol/day, which is equal to a salt intake of 11.1 g/day. Daily urinary sodium excretion was significantly higher in patients with metabolic syndrome compared to those without metabolic syndrome (209 ± 112 mmol/day and 150 ± 62 mmol/day, respectively, p: 0.005). Daily urinary sodium excretion correlated with diastolic blood pressure (r: 0.254, p: 0.028), serum glucose concentration (r: 0.446, p: <0.001), and creatinine clearance (r: 478, p: <0.001). In addition, although there was no significant correlation between daily urinary sodium excretion and systolic blood pressure, the statistical significance was borderline (r: 0.221, p: 0.056).
There is a significant relationship between daily urinary sodium excretion and metabolic syndrome in renal transplant recipients. The Turkish kidney transplantation patients consume a great amount of salt and salt intake is positively correlated with blood pressure.
本研究旨在确定肾移植患者每日尿钠排泄量与代谢综合征之间是否存在关联。
这项横断面研究纳入了76名成年肾移植受者。为计算尿钠排泄量，收集了24小时尿液样本。代谢综合征根据美国心脏协会（AHA）/国立心肺血液研究所（NHLBI）2005年声明中更新的成人治疗小组第三次报告（ATP III）标准进行诊断。
76名患者的平均年龄为38±10岁；76名患者中有21名女性。76名肾移植患者中有52名（68.4%）患有代谢综合征。每日平均尿钠排泄量为190±102 mmol/天，相当于每日盐摄入量为11.1克。与无代谢综合征的患者相比，代谢综合征患者的每日尿钠排泄量显著更高（分别为209±112 mmol/天和150±62 mmol/天，p：0.005）。每日尿钠排泄量与舒张压（r：0.254，p：0.028）、血清葡萄糖浓度（r：0.446，p：<0.001）和肌酐清除率（r：478，p：<0.001）相关。此外，虽然每日尿钠排泄量与收缩压之间无显著相关性，但统计学显著性接近临界值（r：0.221，p：0.056）。
肾移植受者的每日尿钠排泄量与代谢综合征之间存在显著关联。土耳其肾移植患者盐摄入量很大，且盐摄入量与血压呈正相关。
