登革病毒特异性交叉反应性CD8 + 人细胞毒性T淋巴细胞。
Dengue virus-specific cross-reactive CD8+ human cytotoxic T lymphocytes.
作者信息
Bukowski J F, Kurane I, Lai C J, Bray M, Falgout B, Ennis F A
机构信息
Department of Medicine, University of Massachusetts Medical Center, Worcester 01655.
出版信息
J Virol. 1989 Dec;63(12):5086-91. doi: 10.1128/JVI.63.12.5086-5091.1989.
Abstract
Stimulation with live dengue virus of peripheral blood mononuclear cells from a dengue virus type 4-immune donor generated virus-specific, serotype-cross-reactive, CD8+, class I-restricted cytotoxic T lymphocytes (CTL) capable of lysing dengue virus-infected cells and cells pulsed with dengue virus antigens of all four serotypes. These CTL lysed autologous fibroblasts infected with vaccinia virus-dengue virus recombinant viruses containing the E gene or several nonstructural dengue virus type 4 genes. These results demonstrate that both dengue virus structural and nonstructural proteins are targets for the cytotoxic T-cell-mediated immune response to dengue virus and suggest that serotype-cross-reactive CD8+ CTL may be important mediators of viral clearance and of virus-induced immunopathology during secondary dengue virus infections.
摘要
用来自登革病毒4型免疫供体的外周血单个核细胞进行活登革病毒刺激，产生了病毒特异性、血清型交叉反应性、CD8⁺、I类限制性细胞毒性T淋巴细胞（CTL），这些CTL能够裂解登革病毒感染的细胞以及用所有四种血清型的登革病毒抗原脉冲处理的细胞。这些CTL裂解了感染了含有E基因或几种登革病毒4型非结构基因的痘苗病毒-登革病毒重组病毒的自体成纤维细胞。这些结果表明，登革病毒的结构蛋白和非结构蛋白都是细胞毒性T细胞介导的针对登革病毒免疫反应的靶标，并提示血清型交叉反应性CD8⁺ CTL可能是二次登革病毒感染期间病毒清除和病毒诱导的免疫病理的重要介质。
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