纳米技术在放射肿瘤学中的应用。
Nanotechnology in radiation oncology.
机构信息
All authors: Lineberger Comprehensive Cancer Center, Carolina Center for Cancer Nanotechnology Excellence, University of North Carolina at Chapel Hill, Chapel Hill, NC.
出版信息
J Clin Oncol. 2014 Sep 10;32(26):2879-85. doi: 10.1200/JCO.2014.55.0699. Epub 2014 Aug 11.
Nanotechnology, the manipulation of matter on atomic and molecular scales, is a relatively new branch of science. It has already made a significant impact on clinical medicine, especially in oncology. Nanomaterial has several characteristics that are ideal for oncology applications, including preferential accumulation in tumors, low distribution in normal tissues, biodistribution, pharmacokinetics, and clearance, that differ from those of small molecules. Because these properties are also well suited for applications in radiation oncology, nanomaterials have been used in many different areas of radiation oncology for imaging and treatment planning, as well as for radiosensitization to improve the therapeutic ratio. In this article, we review the unique properties of nanomaterials that are favorable for oncology applications and examine the various applications of nanotechnology in radiation oncology. We also discuss the future directions of nanotechnology within the context of radiation oncology.
纳米技术，即原子和分子尺度上的物质操控，是一门相对较新的科学分支。它已经对临床医学产生了重大影响，尤其是在肿瘤学领域。纳米材料具有几种理想的肿瘤学应用特性，包括在肿瘤中的优先积累、在正常组织中的低分布、生物分布、药代动力学和清除率，这些特性与小分子不同。由于这些特性也非常适合放射肿瘤学中的应用，因此纳米材料已被用于放射肿瘤学的许多不同领域，用于成像和治疗计划，以及用于放射增敏以提高治疗比。本文综述了纳米材料在肿瘤学应用中具有优势的独特性质，并探讨了纳米技术在放射肿瘤学中的各种应用。我们还讨论了纳米技术在放射肿瘤学中的未来发展方向。
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