Reisin Efrain, Harris Raymond C, Rahman Mahboob
Section of Nephrology and Hypertension, Louisiana State University Health Science Center, New Orleans, Louisiana;
Division of Nephrology, Vanderbilt University School of Medicine, Nashville, Tennessee; and.
J Am Soc Nephrol. 2014 Nov;25(11):2419-24. doi: 10.1681/ASN.2014040371. Epub 2014 Aug 11.
The recently published article "2014 Evidence-based guideline for the management of high blood pressure in adults: Report from the panel members appointed to the Eighth Joint National Committee (JNC 8)" (James et al., JAMA 311: 507-520, 2014) has generated considerable controversy. In this commentary, we evaluate the document and compare the recommendations contained within it with those of the JNC 7 and other national and international guidelines. The evidence quality rating approach followed by the article "2014 Evidence-based guideline for the management of high blood pressure in adults: Report from the panel members appointed to the Eighth Joint National Committee (JNC 8)" (James et al., JAMA 311: 507-520, 2014) disqualified nearly 98% of previous studies from review; as a result, some of the key recommendations were on the basis of expert opinion alone. We are especially concerned that the recommendation to raise the systolic/diastolic BP levels at which treatment is initiated to ≥150/≥90 mmHg in adults≥60 years old may affect cardiovascular and renal health in these patients. Additionally, we recommend that hypertension guidelines should be updated every 3-4 years with a fresh approach to the definition of target BP levels, the use of modern technology in the diagnosis of hypertension, and the treatment of hypertension in special populations not addressed in earlier guidelines.
最近发表的文章《2014年成人高血压管理循证指南:第八届美国国立联合委员会(JNC 8)指定小组成员报告》(詹姆斯等人,《美国医学会杂志》311: 507 - 520,2014年)引发了相当大的争议。在这篇评论中,我们对该文件进行评估,并将其中包含的建议与JNC 7以及其他国家和国际指南的建议进行比较。《2014年成人高血压管理循证指南:第八届美国国立联合委员会(JNC 8)指定小组成员报告》(詹姆斯等人,《美国医学会杂志》311: 507 - 520,2014年)所采用的证据质量评级方法使近98%的先前研究失去了被审查的资格;因此,一些关键建议仅基于专家意见。我们尤其担心,将60岁及以上成年人开始治疗的收缩压/舒张压水平提高到≥150/≥90 mmHg这一建议可能会影响这些患者的心血管和肾脏健康。此外,我们建议高血压指南应每3 - 4年更新一次,采用全新方法来定义目标血压水平、在高血压诊断中使用现代技术以及治疗早期指南未涉及的特殊人群的高血压。