Constantine the Philosopher University in Nitra, Nitra, Slovak Republic, 2Slovak University of Agriculture in Nitra, Nitra, Slovak Republic.
Physiol Res. 2021 Dec 30;70(Suppl4):S657-S667. doi: 10.33549/physiolres.934711.
Tribulus terrestris, L. (puncture vine) have been used as a folk medicine for five thousands of years, but its targets, effects, their mechanisms and application requires further studies. This paper reviews the provenance, constituents and properties of Tribulus terrestris, L., its general physiological and health effects, as well as the currently available knowledge concerning its influence on male and female reproductive processes and their dysfunctions. Analysis of the available publications demonstrated the influence of Tribulus terrestris on a wide spectrum of targets and physiological processe and disorders. In particular, Tribulus terrestris can be a stimulator of male and female reproductive processes at the level of central nervous system, sexual behaviour, pituitary and gonadal hormones and their receptors, gonadal functions (including ovarian follicullogenesis and spermatogenesis), improvement of the quality and quantity of gametes (at least of sperm) and fecundity. This ability of puncture vine is applicable for the improvement of man's sexual desire and sperm quality in vivo and in vitro, as well as of women's libido, activation of women's reproductive organs, fecundity, and treatment of infertility, especially that related to the polycystic ovarian syndrome.
蒺藜（刺蒺藜）作为一种民间药物已经使用了五千年，但它的靶点、作用、机制和应用需要进一步研究。本文综述了蒺藜的产地、成分和性质，及其对男性和女性生殖过程及其功能障碍的普遍生理和健康影响，以及目前关于其对男性和女性生殖过程及其功能障碍的影响的现有知识。对现有文献的分析表明，蒺藜对广泛的靶点和生理过程及疾病有影响。特别是，蒺藜可以作为中枢神经系统、性行为、垂体和性腺激素及其受体、性腺功能（包括卵巢卵泡发生和精子发生）、改善配子（至少精子）质量和数量以及生育能力的男性和女性生殖过程的刺激物。这种刺蒺藜的能力适用于改善男性的性欲和体内外精子质量，以及女性的性欲、激活女性生殖器官、生育能力，并治疗不孕，特别是与多囊卵巢综合征相关的不孕。
