Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Nutrition Research Center, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran.
Trials. 2022 Aug 19;23(1):689. doi: 10.1186/s13063-022-06630-0.
High intensity and endurance exercises lead to exercise-induced oxidative stress (EIOS), exercise-induced muscle damage (EIMD), and inflammation, which are the influencing factors on muscle soreness, localized swelling, and sports performance decrease. Therefore, the purpose of this study is to determine the effectiveness of Tribulus terrestris (TT) as an herbal supplement with antioxidant and anti-inflammatory properties on the nutritional, oxidative, inflammatory, and anti-inflammatory status, as well as the sports performance of recreational runners.
METHODS/DESIGN: This study is a double-blind, randomized, placebo-controlled trial, which will be conducted among recreational runners of Tabriz stadiums, Iran. Thirty-four recreational runners will be selected, and participants will be assigned randomly to two groups: to receive 500 mg TT supplement or placebo capsules twice daily for 2 weeks. Both groups will do high-intensity interval training (HIIT) workouts during the study. Baseline and post-intervention body composition, muscle pain, and aerobic and anaerobic performance will be assessed. In addition, assessment of malondialdehyde (MDA), total antioxidant capacity (TAC), total oxidant status (TOS), superoxide dismutase (SOD), glutathione peroxidase (GPx), uric acid (UA), 8-iso-prostaglandin F2α (8-iso-PGF2α), protein carbonyl (PC), catalase (CAT), glutathione (GSH), nitric oxide (NO), high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor-alpha (TNF-α), creatine kinase (CK), myoglobin (MYO), lactate dehydrogenase (LDH), insulin-like growth factor-1 (IGF-1) irisin, cortisol, and brain-derived neurotrophic factor (BDNF) will be done during three blood samplings. Changes in oxidative stress, anti/inflammatory biomarkers, and sports performance will be assessed as primary outcomes.
This study will be the first to assess the potential effects of TT on recreational runners. Our results will contribute to the growing body of knowledge regarding TT supplementation on the nutritional, oxidative, inflammatory, and anti-inflammatory status and sports performance in recreational runners.
Iranian Registry of Clinical Trials ( www.irct.ir ) (ID: IRCT20150205020965N8 ). Registration date: 13 February 2021.
高强度和耐力运动导致运动引起的氧化应激（EIOS）、运动引起的肌肉损伤（EIMD）和炎症，这些都是肌肉酸痛、局部肿胀和运动表现下降的影响因素。因此，本研究的目的是确定 Tribulus terrestris（TT）作为一种具有抗氧化和抗炎特性的草药补充剂，对营养、氧化、炎症和抗炎状态以及娱乐跑步者的运动表现的有效性。
方法/设计：这是一项双盲、随机、安慰剂对照试验，将在伊朗大不里士体育场的娱乐跑者中进行。将选择 34 名娱乐跑者，并将参与者随机分配到两组：每天两次服用 500 毫克 TT 补充剂或安慰剂胶囊，持续 2 周。两组在研究期间都将进行高强度间歇训练（HIIT）锻炼。在干预前后评估身体成分、肌肉疼痛和有氧及无氧表现。此外，还将评估丙二醛（MDA）、总抗氧化能力（TAC）、总氧化状态（TOS）、超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GPx）、尿酸（UA）、8-异前列腺素 F2α（8-iso-PGF2α）、蛋白羰基（PC）、过氧化氢酶（CAT）、谷胱甘肽（GSH）、一氧化氮（NO）、高敏 C 反应蛋白（hs-CRP）、白细胞介素 6（IL-6）、白细胞介素 10（IL-10）、肿瘤坏死因子-α（TNF-α）、肌酸激酶（CK）、肌红蛋白（MYO）、乳酸脱氢酶（LDH）、胰岛素样生长因子-1（IGF-1）鸢尾素、皮质醇和脑源性神经营养因子（BDNF）将在三次采血期间进行。氧化应激、抗/炎症生物标志物和运动表现的变化将作为主要结果进行评估。
这项研究将首次评估 TT 对娱乐跑者的潜在影响。我们的结果将有助于增加关于 TT 补充剂对娱乐跑者营养、氧化、炎症和抗炎状态以及运动表现的知识。
伊朗临床试验注册中心（www.irct.ir）（ID：IRCT20150205020965N8）。注册日期：2021 年 2 月 13 日。
